Alternative isoforms of KDM2A and KDM2B lysine demethylases negatively regulate canonical Wnt signaling

Dijana Lađinović; Daniel Pinkas; Tijana Šopin; Otakar Raška; František Liška; Ivan Raška; Tomáš Vacík

doi:10.1371/journal.pone.0236612

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Open Access

Peer-reviewed

Research Article

Alternative isoforms of KDM2A and KDM2B lysine demethylases negatively regulate canonical Wnt signaling

Dijana Lađinović ,

Contributed equally to this work with: Dijana Lađinović, Daniel Pinkas

Roles Investigation, Visualization

Affiliation Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic
⨯
Daniel Pinkas ,

Contributed equally to this work with: Dijana Lađinović, Daniel Pinkas

Roles Investigation, Visualization

Affiliation Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic
⨯
Tijana Šopin,

Roles Investigation

Affiliation Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic
⨯
Otakar Raška,

Roles Investigation, Visualization

Affiliation Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic
⨯
František Liška,

Roles Investigation, Visualization

Affiliation Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic
⨯
Ivan Raška,

Roles Funding acquisition, Writing – review & editing

Affiliation Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic
⨯
Tomáš Vacík

Roles Conceptualization, Investigation, Supervision, Visualization, Writing – original draft

* E-mail: tomas.vacik@lf1.cuni.cz

Affiliation Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic

https://orcid.org/0000-0003-0797-7757

⨯

Alternative isoforms of KDM2A and KDM2B lysine demethylases negatively regulate canonical Wnt signaling

Dijana Lađinović,
Daniel Pinkas,
Tijana Šopin,
Otakar Raška,
František Liška,
Ivan Raška,
Tomáš Vacík

Published: October 26, 2020
https://doi.org/10.1371/journal.pone.0236612

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Cyclins
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Luciferase
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DNA methylation
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Wnt signaling cascade
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DNA transcription
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Promoter regions
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DNA-binding proteins
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