Tentative identification of gefitinib metabolites in non-small-cell lung cancer patient plasma using ultra-performance liquid chromatography coupled with triple quadrupole time-of-flight mass spectrometry

Chao Wang; Jingui Zhang; Simin Zhou; Limei Yu; Fangxuan Han; Ren Ling; Jin Ling

doi:10.1371/journal.pone.0236523

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Open Access

Peer-reviewed

Research Article

Tentative identification of gefitinib metabolites in non-small-cell lung cancer patient plasma using ultra-performance liquid chromatography coupled with triple quadrupole time-of-flight mass spectrometry

Chao Wang ,

Contributed equally to this work with: Chao Wang, Jingui Zhang, Simin Zhou

Roles Conceptualization, Investigation, Methodology, Project administration, Writing – original draft

* E-mail: wch_22001923@163.com (CW); ttelva@foxmail.com (JL)

Affiliation Department of Pharmacy, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China

http://orcid.org/0000-0002-8592-3781

⨯
Jingui Zhang ,

Contributed equally to this work with: Chao Wang, Jingui Zhang, Simin Zhou

Roles Data curation, Investigation, Methodology, Validation

Affiliation Phase I Clinical Trial Ward/Department of Pharmacy, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China
⨯
Simin Zhou ,

Contributed equally to this work with: Chao Wang, Jingui Zhang, Simin Zhou

Roles Investigation, Software, Writing – review & editing

Affiliation Department of Pharmacy, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China
⨯
Limei Yu,

Roles Writing – review & editing

Affiliation Department of Function Examination, the Children’s Hospital of Jiangxi Province, Nanchang, Jiangxi, China
⨯
Fangxuan Han,

Roles Data curation, Investigation

Affiliation Phase I Clinical Trial Ward/Department of Pharmacy, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China
⨯
Ren Ling,

Roles Funding acquisition, Resources

Affiliation Department of Pathology, Zhejiang Jinhua Guangfu Hospital, Jinhua, Zhejiang, China
⨯
Jin Ling

Roles Conceptualization, Investigation, Methodology

* E-mail: wch_22001923@163.com (CW); ttelva@foxmail.com (JL)

Affiliations Department of Pharmacy, Zhejiang Jinhua Guangfu Hospital, Jinhua, Zhejiang, China, Department of Pharmaceutical Analysis, School of Pharmacy, Fudan University, Shanghai, China
⨯

Tentative identification of gefitinib metabolites in non-small-cell lung cancer patient plasma using ultra-performance liquid chromatography coupled with triple quadrupole time-of-flight mass spectrometry

Chao Wang,
Jingui Zhang,
Simin Zhou,
Limei Yu,
Fangxuan Han,
Ren Ling,
Jin Ling

Published: July 23, 2020
https://doi.org/10.1371/journal.pone.0236523

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