Extracellular vesicles from human plasma and serum are carriers of extravesicular cargo—Implications for biomarker discovery

• Mari Palviainen,

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  Affiliations EV group, Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland, EV-core, University of Helsinki, Helsinki, Finland, CURED, Drug Research Program, Faculty of Pharmacy, Division of Pharmaceutical Biosciences, University of Helsinki, Helsinki, Finland

  http://orcid.org/0000-0002-7105-3543

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• Mayank Saraswat,

  Roles Investigation, Methodology, Writing – original draft

  Affiliations Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland, HUS Diagnostic Center, Helsinki University Hospital, Helsinki, Finland

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• Zoltán Varga,

  Roles Formal analysis, Methodology, Validation, Writing – review & editing

  Affiliation Biological Nanochemistry Research Group, Research Centre for Natural Sciences, Institute of Materials and Environmental Chemistry, Budapest, Hungary

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• Diána Kitka,

  Roles Formal analysis, Investigation, Validation

  Affiliation Biological Nanochemistry Research Group, Research Centre for Natural Sciences, Institute of Materials and Environmental Chemistry, Budapest, Hungary

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• Maarit Neuvonen,

  Roles Investigation

  Affiliations EV group, Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland, EV-core, University of Helsinki, Helsinki, Finland, CURED, Drug Research Program, Faculty of Pharmacy, Division of Pharmaceutical Biosciences, University of Helsinki, Helsinki, Finland

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• Maija Puhka,

  Roles Investigation

  Affiliations EV-core, University of Helsinki, Helsinki, Finland, Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland

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• Sakari Joenväärä,

  Roles Data curation, Investigation

  Affiliations Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland, HUS Diagnostic Center, Helsinki University Hospital, Helsinki, Finland

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• Risto Renkonen,

  Roles Funding acquisition, Resources

  Affiliations Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland, HUS Diagnostic Center, Helsinki University Hospital, Helsinki, Finland

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• Rienk Nieuwland,

  Roles Writing – review & editing

  Affiliations Laboratory Experimental Clinical Chemistry, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands, Vesicle Observation Center, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

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• Maarit Takatalo,

  Roles Conceptualization, Investigation, Methodology, Writing – original draft

  Affiliations EV group, Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland, EV-core, University of Helsinki, Helsinki, Finland, CURED, Drug Research Program, Faculty of Pharmacy, Division of Pharmaceutical Biosciences, University of Helsinki, Helsinki, Finland

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• Pia R. M. Siljander

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

  * E-mail: pia.siljander@helsinki.fi

  Affiliations EV group, Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland, EV-core, University of Helsinki, Helsinki, Finland, CURED, Drug Research Program, Faculty of Pharmacy, Division of Pharmaceutical Biosciences, University of Helsinki, Helsinki, Finland

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