Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes

• Shauna D. O’Donovan ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

  * E-mail: shauna.odonovan@wur.nl

  Affiliations Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands, Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, The Netherlands

  http://orcid.org/0000-0003-2253-4903

  ⨯
• Kurt Driessens,

  Roles Conceptualization, Data curation, Methodology, Software, Writing – review & editing

  Affiliation Dept. of Data Science and Knowledge Engineering, Maastricht University, Maastricht, The Netherlands

  ⨯
• Daniel Lopatta,

  Roles Data curation, Formal analysis, Investigation, Software, Validation, Visualization, Writing – review & editing

  Affiliation Dept. of Data Science and Knowledge Engineering, Maastricht University, Maastricht, The Netherlands

  ⨯
• Florian Wimmenauer,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – review & editing

  Affiliation Dept. of Data Science and Knowledge Engineering, Maastricht University, Maastricht, The Netherlands

  ⨯
• Alexander Lukas,

  Roles Data curation, Formal analysis, Investigation, Software, Validation, Visualization, Writing – review & editing

  Affiliation Dept. of Data Science and Knowledge Engineering, Maastricht University, Maastricht, The Netherlands

  ⨯
• Jelmer Neeven,

  Roles Data curation, Formal analysis, Investigation, Software, Validation, Visualization, Writing – review & editing

  Affiliation Dept. of Data Science and Knowledge Engineering, Maastricht University, Maastricht, The Netherlands

  ⨯
• Tobias Stumm,

  Roles Data curation, Formal analysis, Investigation, Software, Validation, Visualization, Writing – review & editing

  Affiliation Dept. of Data Science and Knowledge Engineering, Maastricht University, Maastricht, The Netherlands

  ⨯
• Evgueni Smirnov,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Dept. of Data Science and Knowledge Engineering, Maastricht University, Maastricht, The Netherlands

  ⨯
• Michael Lenz,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Writing – review & editing

  Affiliations Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands, Institute of Organismic and Molecular Evolution, Johannes Gutenberg University Mainz, Mainz, Germany, Preventive Cardiology and Preventative Medicine—Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

  ⨯
• Gokhan Ertaylan,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Writing – review & editing

  Affiliations Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands, Flemish Institute for Technological Research (VITO), Mol, Belgium

  ⨯
• Danyel G. J. Jennen,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Dept. of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands

  ⨯
• Natal A. W. van Riel,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing

  Affiliations Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands, Dept. of Biomedical Engineering, Eindhoven University of Technology, The Netherlands

  ⨯
• Rachel Cavill,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Dept. of Data Science and Knowledge Engineering, Maastricht University, Maastricht, The Netherlands

  ⨯
• Ralf L. M. Peeters,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

  Affiliations Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands, Dept. of Data Science and Knowledge Engineering, Maastricht University, Maastricht, The Netherlands

  ⨯
• Theo M. C. M. de Kok

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

  Affiliations Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands, Dept. of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands

  ⨯