Hydrophobicity drives receptor-mediated uptake of heat-processed proteins by THP-1 macrophages and dendritic cells, but not cytokine responses

Ying Deng; Coen Govers; Malgorzata Teodorowicz; Ieva Liobyte; Ilaria De Simone; Kasper Hettinga; Harry J. Wichers

doi:10.1371/journal.pone.0236212

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Open Access

Peer-reviewed

Research Article

Hydrophobicity drives receptor-mediated uptake of heat-processed proteins by THP-1 macrophages and dendritic cells, but not cytokine responses

Ying Deng,

Roles Data curation, Investigation, Methodology, Writing – original draft

Affiliations Food and Biobased Research, Wageningen University and Research, Wageningen, The Netherlands, Laboratory of Food Chemistry, Wageningen University and Research, Wageningen, The Netherlands
⨯
Coen Govers,

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation Food and Biobased Research, Wageningen University and Research, Wageningen, The Netherlands
⨯
Malgorzata Teodorowicz,

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation Cell Biology and Immunology, Wageningen University and Research, Wageningen, The Netherlands
⨯
Ieva Liobyte,

Roles Data curation, Formal analysis

Affiliations Food and Biobased Research, Wageningen University and Research, Wageningen, The Netherlands, Laboratory of Food Chemistry, Wageningen University and Research, Wageningen, The Netherlands
⨯
Ilaria De Simone,

Roles Data curation, Formal analysis

Affiliations Food and Biobased Research, Wageningen University and Research, Wageningen, The Netherlands, Cell Biology and Immunology, Wageningen University and Research, Wageningen, The Netherlands
⨯
Kasper Hettinga,

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation Food Quality and Design, Wageningen University and Research, Wageningen, The Netherlands
⨯
Harry J. Wichers

Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

* E-mail: harry.wichers@wur.nl

Affiliations Food and Biobased Research, Wageningen University and Research, Wageningen, The Netherlands, Laboratory of Food Chemistry, Wageningen University and Research, Wageningen, The Netherlands

http://orcid.org/0000-0002-8030-7090

⨯

Hydrophobicity drives receptor-mediated uptake of heat-processed proteins by THP-1 macrophages and dendritic cells, but not cytokine responses

Ying Deng,
Coen Govers,
Malgorzata Teodorowicz,
Ieva Liobyte,
Ilaria De Simone,
Kasper Hettinga,
Harry J. Wichers

Published: August 14, 2020
https://doi.org/10.1371/journal.pone.0236212

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