An Angelman syndrome substitution in the HECT E3 ubiquitin ligase C-terminal Lobe of E6AP affects protein stability and activity

• Steven A. Beasley,

  Roles Data curation, Formal analysis, Software, Validation, Writing – original draft, Writing – review & editing

  Affiliation Gustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA, United States of America

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• Chloe E. Kellum,

  Roles Conceptualization, Data curation, Writing – original draft

  Affiliation Gustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA, United States of America

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• Rachel J. Orlomoski,

  Roles Conceptualization, Data curation, Writing – review & editing

  Affiliation Gustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA, United States of America

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• Feston Idrizi,

  Roles Conceptualization, Data curation

  Affiliation Gustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA, United States of America

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• Donald E. Spratt

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: dspratt@clarku.edu

  Affiliation Gustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA, United States of America

  http://orcid.org/0000-0002-0699-155X

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