Methylglyoxal and D-lactate in cisplatin-induced acute kidney injury: Investigation of the potential mechanism via fluorogenic derivatization liquid chromatography-tandem mass spectrometry (FD-LC-MS/MS) proteomic analysis

Shih-Ming Chen; Tsung-Hui Chen; Hui-Ting Chang; Tzu-Yao Lin; Chia-Yu Lin; Pei-Yun Tsai; Kazuhiro Imai; Chien-Ming Chen; Jen-Ai Lee

doi:10.1371/journal.pone.0235849

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Open Access

Peer-reviewed

Research Article

Methylglyoxal and D-lactate in cisplatin-induced acute kidney injury: Investigation of the potential mechanism via fluorogenic derivatization liquid chromatography-tandem mass spectrometry (FD-LC-MS/MS) proteomic analysis

Shih-Ming Chen,

Roles Funding acquisition, Methodology

Affiliation Department of Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan
⨯
Tsung-Hui Chen,

Roles Project administration, Writing – original draft

Affiliation Department of Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan
⨯
Hui-Ting Chang,

Roles Project administration

Affiliations Department of Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan, Department of Health, Taipei City Government, Taipei, Taiwan
⨯
Tzu-Yao Lin,

Roles Project administration, Writing – review & editing

Affiliation Department of Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan
⨯
Chia-Yu Lin,

Roles Project administration, Writing – review & editing

Affiliations Department of Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan, Department of Pharmacy, Taipei Medical University Hospital, Taipei, Taiwan
⨯
Pei-Yun Tsai,

Roles Formal analysis, Project administration

Affiliations Department of Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan, Department of Pharmacy, Wan-Fang Hospital, Taipei, Taiwan
⨯
Kazuhiro Imai,

Roles Supervision, Writing – review & editing

Affiliation Research Institute of Pharmaceutical Sciences, Musashino University, Tokyo, Japan
⨯
Chien-Ming Chen,

Roles Resources, Software, Supervision

Affiliation Department of Electro-Optical Engineering, National Taipei University of Technology, Taipei, Taiwan
⨯
Jen-Ai Lee

Roles Conceptualization, Methodology, Writing – review & editing

* E-mail: jenai@tmu.edu.tw

Affiliation Department of Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan

http://orcid.org/0000-0002-6080-8736

⨯

Methylglyoxal and D-lactate in cisplatin-induced acute kidney injury: Investigation of the potential mechanism via fluorogenic derivatization liquid chromatography-tandem mass spectrometry (FD-LC-MS/MS) proteomic analysis

Shih-Ming Chen,
Tsung-Hui Chen,
Hui-Ting Chang,
Tzu-Yao Lin,
Chia-Yu Lin,
Pei-Yun Tsai,
Kazuhiro Imai,
Chien-Ming Chen,
Jen-Ai Lee

Published: July 10, 2020
https://doi.org/10.1371/journal.pone.0235849

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Oxidative stress
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Proteomics
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