Complementary epitopes and favorable developability of monoclonal anti-LAMP1 antibodies generated using two transgenic animal platforms

Beatrice Cameron; Tarik Dabdoubi; Laurence Berthou-Soulié; Marie Gagnaire; Isabelle Arnould; Anne Severac; Fabienne Soubrier; Jacqueline Morales; Philip A. Leighton; William Harriman; Kathryn Ching; Yasmina Abdiche; Katarina Radošević; Thomas Bouquin

doi:10.1371/journal.pone.0235815

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Open Access

Peer-reviewed

Research Article

Complementary epitopes and favorable developability of monoclonal anti-LAMP1 antibodies generated using two transgenic animal platforms

Beatrice Cameron,

Roles Supervision, Writing – original draft, Writing – review & editing

Affiliation Biologics Research, Sanofi R&D, Boufféré, France
⨯
Tarik Dabdoubi,

Roles Investigation, Supervision, Visualization

Affiliation Biologics Research, Sanofi R&D, Boufféré, France
⨯
Laurence Berthou-Soulié,

Roles Software, Visualization

Affiliation Biologics Research, Sanofi R&D, Boufféré, France
⨯
Marie Gagnaire,

Roles Investigation, Supervision, Visualization

Affiliation Biologics Research, Sanofi R&D, Boufféré, France

http://orcid.org/0000-0002-4993-3421

⨯
Isabelle Arnould,

Roles Methodology, Supervision, Validation

Affiliation Biologics Research, Sanofi R&D, Boufféré, France

http://orcid.org/0000-0003-0065-5683

⨯
Anne Severac,

Roles Investigation, Supervision, Visualization

Affiliation Biologics Research, Sanofi R&D, Boufféré, France
⨯
Fabienne Soubrier,

Roles Investigation, Supervision

Affiliation Biologics Research, Sanofi R&D, Boufféré, France
⨯
Jacqueline Morales,

Roles Investigation, Resources

Affiliation Ligand Pharmaceuticals Inc., San Diego, California, United States of America
⨯
Philip A. Leighton,

Roles Investigation, Supervision

Affiliation Ligand Pharmaceuticals Inc., San Diego, California, United States of America

http://orcid.org/0000-0002-6575-129X

⨯
William Harriman,

Roles Supervision, Writing – original draft

Affiliation Ligand Pharmaceuticals Inc., San Diego, California, United States of America
⨯
Kathryn Ching,

Roles Investigation, Supervision

Affiliation Ligand Pharmaceuticals Inc., San Diego, California, United States of America

http://orcid.org/0000-0002-1932-1504

⨯
Yasmina Abdiche,

Roles Supervision

Affiliation Carterra Inc., Salt Lake City, Utah, United States of America
⨯
Katarina Radošević,

Roles Conceptualization

Affiliation Biologics Research, Sanofi R&D, Boufféré, France
⨯
Thomas Bouquin

Roles Conceptualization, Supervision, Writing – original draft

* E-mail: thomas.bouquin@sanofi.com

Affiliation Biologics Research, Sanofi R&D, Boufféré, France

http://orcid.org/0000-0002-9597-8137

⨯

Complementary epitopes and favorable developability of monoclonal anti-LAMP1 antibodies generated using two transgenic animal platforms

Beatrice Cameron,
Tarik Dabdoubi,
Laurence Berthou-Soulié,
Marie Gagnaire,
Isabelle Arnould,
Anne Severac,
Fabienne Soubrier,
Jacqueline Morales,
Philip A. Leighton,
William Harriman

Published: July 16, 2020
https://doi.org/10.1371/journal.pone.0235815

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26 Jul 2020
20:44 GMT
Most Recent

Correct name for Immunogenicity Analysis Platform used in this antibody development pipeline is ISPRI Posted by Annie_De_Groot on 26 Jul 2020 at 20:44 GMT

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