Kinome capture sequencing of high-grade serous ovarian carcinoma reveals novel mutations in the JAK3 gene

Lorenza Mittempergher; Anna M. Piskorz; Astrid J. Bosma; Magali Michaut; G. Bea A. Wisman; Roelof J. C. Kluin; Marja Nieuwland; Wim Brugman; Kevin J. W. van der Ven; Francesco Marass; James Morris; Nitzan Rosenfeld; Mercedes Jimenez-Linan; Steven de Jong; Ate G. J. van der Zee; James D. Brenton; René Bernards

doi:10.1371/journal.pone.0235766

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Peer-reviewed

Research Article

Kinome capture sequencing of high-grade serous ovarian carcinoma reveals novel mutations in the JAK3 gene

Lorenza Mittempergher ,

Contributed equally to this work with: Lorenza Mittempergher, Anna M. Piskorz

Roles Conceptualization, Data curation, Formal analysis, Investigation, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands

http://orcid.org/0000-0003-3425-3965

⨯
Anna M. Piskorz ,

Contributed equally to this work with: Lorenza Mittempergher, Anna M. Piskorz

Roles Data curation, Formal analysis, Investigation, Resources, Validation, Writing – review & editing

Affiliation Cancer Research UK Cambridge Institute University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom
⨯
Astrid J. Bosma,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands
⨯
Magali Michaut,

Roles Formal analysis, Investigation, Software, Visualization

Affiliation Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands
⨯
G. Bea A. Wisman,

Roles Data curation, Investigation, Methodology, Resources, Validation, Writing – review & editing

Affiliation Department of Gynecologic Oncology, Cancer Research Center Groningen, University of Groningen, Groningen, The Netherlands
⨯
Roelof J. C. Kluin,

Roles Formal analysis, Software, Visualization, Writing – review & editing

Affiliation Genomics Core Facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands
⨯
Marja Nieuwland,

Roles Investigation, Methodology

Affiliation Genomics Core Facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands
⨯
Wim Brugman,

Roles Investigation, Methodology

Affiliation Genomics Core Facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands
⨯
Kevin J. W. van der Ven,

Roles Methodology, Resources

Affiliation Department of Pathology, University Medical Centre Utrecht, Utrecht, The Netherlands
⨯
Francesco Marass,

Roles Formal analysis

Affiliations Cancer Research UK Cambridge Institute University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom, Department of Biosystems Science and Engineering and Swiss Institute of Bioinformatics, ETH Zurich, Basel, Switzerland

http://orcid.org/0000-0002-8993-7320

⨯
James Morris,

Roles Formal analysis

Affiliation Cancer Research UK Cambridge Institute University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom
⨯
Nitzan Rosenfeld,

Roles Formal analysis

Affiliation Cancer Research UK Cambridge Institute University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom
⨯
Mercedes Jimenez-Linan,

Roles Investigation

Affiliations Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, Cambridge, United Kingdom, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom
⨯
Steven de Jong,

Roles Investigation, Methodology, Resources, Writing – review & editing

Affiliation Department of Medical Oncology, Cancer Research Center Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
⨯
Ate G. J. van der Zee,

Roles Conceptualization, Supervision

Affiliation Department of Gynecologic Oncology, Cancer Research Center Groningen, University of Groningen, Groningen, The Netherlands
⨯
James D. Brenton ,

Roles Conceptualization, Data curation, Investigation, Resources, Supervision, Validation, Writing – review & editing

* E-mail: r.bernards@nki.nl (RB); James.Brenton@cruk.cam.ac.uk (JDB)

Affiliation Cancer Research UK Cambridge Institute University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom
⨯
[ ... ],
René Bernards

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Supervision, Writing – review & editing

* E-mail: r.bernards@nki.nl (RB); James.Brenton@cruk.cam.ac.uk (JDB)

Affiliation Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands
⨯
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Kinome capture sequencing of high-grade serous ovarian carcinoma reveals novel mutations in the JAK3 gene

Lorenza Mittempergher,
Anna M. Piskorz,
Astrid J. Bosma,
Magali Michaut,
G. Bea A. Wisman,
Roelof J. C. Kluin,
Marja Nieuwland,
Wim Brugman,
Kevin J. W. van der Ven,
Francesco Marass

Published: July 8, 2020
https://doi.org/10.1371/journal.pone.0235766

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