Piperidine scaffold as the novel P2-ligands in cyclopropyl-containing HIV-1 protease inhibitors: Structure-based design, synthesis, biological evaluation and docking study

Huiyu Zhou; Mei Zhu; Ling Ma; Jinming Zhou; Biao Dong; Guoning Zhang; Shan Cen; Yucheng Wang; Juxian Wang

doi:10.1371/journal.pone.0235483

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Open Access

Peer-reviewed

Research Article

Piperidine scaffold as the novel P2-ligands in cyclopropyl-containing HIV-1 protease inhibitors: Structure-based design, synthesis, biological evaluation and docking study

Huiyu Zhou,

Roles Investigation, Writing – original draft

Affiliation Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
⨯
Mei Zhu,

Roles Methodology, Writing – review & editing

Affiliation Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
⨯
Ling Ma,

Roles Formal analysis, Investigation

Affiliation Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
⨯
Jinming Zhou,

Roles Investigation

Affiliation Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Department of Chemistry, Zhejiang Normal University, Jinhua, China
⨯
Biao Dong,

Roles Investigation

Affiliation Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
⨯
Guoning Zhang,

Roles Data curation

Affiliation Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China

http://orcid.org/0000-0003-1736-6749

⨯
Shan Cen,

Roles Investigation, Resources

Affiliation Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
⨯
Yucheng Wang ,

Roles Resources, Writing – review & editing

* E-mail: wyc9999@126.com (YW); imbjxwang@163.com (JW)

Affiliation Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
⨯
Juxian Wang

Roles Supervision, Writing – review & editing

* E-mail: wyc9999@126.com (YW); imbjxwang@163.com (JW)

Affiliation Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China

http://orcid.org/0000-0002-9000-1132

⨯

Piperidine scaffold as the novel P2-ligands in cyclopropyl-containing HIV-1 protease inhibitors: Structure-based design, synthesis, biological evaluation and docking study

Huiyu Zhou,
Mei Zhu,
Ling Ma,
Jinming Zhou,
Biao Dong,
Guoning Zhang,
Shan Cen,
Yucheng Wang,
Juxian Wang

Published: July 22, 2020
https://doi.org/10.1371/journal.pone.0235483

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