The role of serum inflammatory cytokines and berberine in the insulin signaling pathway among women with polycystic ovary syndrome

Hongying Kuang; Yuwei Duan; Dan Li; Yanwen Xu; Wenxia Ai; Wei Li; Ying Wang; Sha Liu; Mushan Li; Xiaoqiu Liu; Manqi Shao

doi:10.1371/journal.pone.0235404

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Open Access

Peer-reviewed

Research Article

The role of serum inflammatory cytokines and berberine in the insulin signaling pathway among women with polycystic ovary syndrome

Hongying Kuang ,

Contributed equally to this work with: Hongying Kuang, Yuwei Duan

Roles Funding acquisition, Writing – original draft

Affiliations The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China, Heilongjiang University of Chinese Medicine, Harbin, China
⨯
Yuwei Duan ,

Contributed equally to this work with: Hongying Kuang, Yuwei Duan

Roles Conceptualization, Writing – original draft

Affiliations The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, Guangdong Provincial Key Laboratory of Reproductive Medicine, Guangzhou, China
⨯
Dan Li ,

Roles Writing – review & editing

* E-mail: 3509437@qq.com (DL); Xuyanwen@live.cn (YX)

Current address: The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

Affiliation Department of Acupuncture, the Third Affiliated Hospital, Beijing University Of Chinese Medicine, Beijing, China

http://orcid.org/0000-0002-5010-5703

⨯
Yanwen Xu ,

Roles Writing – review & editing

* E-mail: 3509437@qq.com (DL); Xuyanwen@live.cn (YX)

Current address: Reproductive Medicine Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China

Affiliations The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, Guangdong Provincial Key Laboratory of Reproductive Medicine, Guangzhou, China
⨯
Wenxia Ai,

Roles Writing – original draft, Writing – review & editing

Affiliation Heilongjiang University of Chinese Medicine, Harbin, China
⨯
Wei Li,

Roles Conceptualization, Data curation, Formal analysis, Writing – review & editing

Affiliation The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China
⨯
Ying Wang,

Roles Writing – review & editing

Affiliation The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China
⨯
Sha Liu,

Roles Writing – review & editing

Affiliation Heilongjiang University of Chinese Medicine, Harbin, China
⨯
Mushan Li,

Roles Writing – review & editing

Affiliation Heilongjiang University of Chinese Medicine, Harbin, China
⨯
Xiaoqiu Liu,

Roles Writing – review & editing

Affiliation Heilongjiang University of Chinese Medicine, Harbin, China
⨯
Manqi Shao

Roles Software, Writing – review & editing

Affiliation Heilongjiang University of Chinese Medicine, Harbin, China
⨯

The role of serum inflammatory cytokines and berberine in the insulin signaling pathway among women with polycystic ovary syndrome

Hongying Kuang,
Yuwei Duan,
Dan Li,
Yanwen Xu,
Wenxia Ai,
Wei Li,
Ying Wang,
Sha Liu,
Mushan Li,
Xiaoqiu Liu

Published: August 12, 2020
https://doi.org/10.1371/journal.pone.0235404

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Polycystic ovary syndrome
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Inflammation
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Cytokines
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Insulin
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Granulosa cells
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Insulin resistance
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Eggs
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Gene expression
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