3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors

• Luned M. Badder ,

  Contributed equally to this work with: Luned M. Badder, Andrew J. Hollins

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft

  Affiliations Cardiff University School of Biosciences, Cardiff, Wales, United Kingdom, European Cancer Stem Cell Research Institute (ECSCRI), Cardiff University, Cardiff, Wales, United Kingdom

  ⨯
• Andrew J. Hollins ,

  Contributed equally to this work with: Luned M. Badder, Andrew J. Hollins

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliations Cardiff University School of Biosciences, Cardiff, Wales, United Kingdom, European Cancer Stem Cell Research Institute (ECSCRI), Cardiff University, Cardiff, Wales, United Kingdom

  ⨯
• Bram Herpers,

  Roles Data curation, Formal analysis, Investigation, Resources, Software, Writing – review & editing

  Affiliation OcellO B.V., Leiden, The Netherlands

  ⨯
• Kuan Yan,

  Roles Data curation, Formal analysis, Investigation, Resources, Software

  Affiliation OcellO B.V., Leiden, The Netherlands

  http://orcid.org/0000-0003-4143-3569

  ⨯
• Kenneth B. Ewan,

  Roles Formal analysis, Investigation, Methodology, Resources, Validation

  Affiliation Cardiff University School of Biosciences, Cardiff, Wales, United Kingdom

  ⨯
• Mairian Thomas,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Cellesce Ltd, Cardiff Medicentre, Heath Park, Cardiff, United Kingdom

  ⨯
• Jennifer R. Shone,

  Roles Formal analysis, Investigation, Validation

  Affiliation Cardiff University School of Biosciences, Cardiff, Wales, United Kingdom

  ⨯
• Delyth A. Badder,

  Roles Investigation, Resources

  Affiliation Cellular Pathology Department, University Hospital for Wales, Cardiff, United Kingdom

  ⨯
• Marc Naven,

  Roles Data curation, Formal analysis, Resources, Software

  Affiliation Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom

  ⨯
• Kevin E. Ashelford,

  Roles Data curation, Formal analysis, Resources, Software

  Affiliation Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom

  ⨯
• Rachel Hargest,

  Roles Resources

  Affiliations Department of Colorectal Surgery, University Hospital of Wales, Cardiff, United Kingdom, Division of Cancer and Genetics, CCMRC, Henry Wellcome Building, Cardiff University, Cardiff, United Kingdom

  ⨯
• Alan R. Clarke †,

  † Deceased.

  Roles Conceptualization, Funding acquisition, Supervision, Validation

  Affiliation European Cancer Stem Cell Research Institute (ECSCRI), Cardiff University, Cardiff, Wales, United Kingdom

  ⨯
• Christina Esdar,

  Roles Investigation, Resources

  Affiliation Biopharma, Merck Healthcare KGaA, Research & Development, Darmstadt, Germany

  ⨯
• Hans-Peter Buchstaller,

  Roles Investigation, Resources

  Affiliation Biopharma, Merck Healthcare KGaA, Research & Development, Darmstadt, Germany

  ⨯
• J. Mark Treherne,

  Roles Resources

  Affiliation Cellesce Ltd, Cardiff Medicentre, Heath Park, Cardiff, United Kingdom

  ⨯
• Sylvia Boj,

  Roles Methodology, Resources

  Affiliation Hubrecht Organoid Technology, Utrecht, The Netherlands

  ⨯
• Bahar Ramezanpour,

  Roles Methodology, Resources

  Affiliation Hubrecht Organoid Technology, Utrecht, The Netherlands

  ⨯
• Dirk Wienke,

  Roles Conceptualization, Resources, Writing – review & editing

  Affiliation Biopharma, Merck Healthcare KGaA, Research & Development, Darmstadt, Germany

  ⨯
• Leo S. Price,

  Roles Conceptualization, Project administration, Writing – review & editing

  Affiliation OcellO B.V., Leiden, The Netherlands

  ⨯
• Paul H. Shaw,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision

  Affiliation Velindre Cancer Centre, Cardiff, Wales, United Kingdom

  ⨯
•  [ ... ],
• Trevor C. Dale

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: DaleTC@cardiff.ac.uk

  Affiliation European Cancer Stem Cell Research Institute (ECSCRI), Cardiff University, Cardiff, Wales, United Kingdom

  http://orcid.org/0000-0002-4880-9963

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