Trastuzumab effects depend on HER2 phosphorylation in HER2-negative breast cancer cell lines

Anna Burguin; Daniela Furrer; Geneviève Ouellette; Simon Jacob; Caroline Diorio; Francine Durocher

doi:10.1371/journal.pone.0234991

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Open Access

Peer-reviewed

Research Article

Trastuzumab effects depend on HER2 phosphorylation in HER2-negative breast cancer cell lines

Anna Burguin,

Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations Centre de recherche sur le cancer, Centre de recherche du CHU de Québec-Université Laval, Québec, Canada, Département de médecine moléculaire, Faculté de médecine, Université Laval, Québec, Canada
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Daniela Furrer,

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliations Centre de recherche sur le cancer, Centre de recherche du CHU de Québec-Université Laval, Québec, Canada, Département de médecine sociale et préventive, Faculté de médecine, Université Laval, Québec, Canada
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Geneviève Ouellette,

Roles Investigation, Writing – review & editing

Affiliations Centre de recherche sur le cancer, Centre de recherche du CHU de Québec-Université Laval, Québec, Canada, Département de médecine moléculaire, Faculté de médecine, Université Laval, Québec, Canada
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Simon Jacob,

Roles Resources, Writing – review & editing

Affiliations Laboratoire de pathologie, Hôpital du Saint-Sacrement, CHU de Québec-Université Laval, Québec, Canada, Centre des Maladies du Sein, Hôpital du Saint-Sacrement, Québec, Canada
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Caroline Diorio,

Roles Conceptualization, Methodology, Resources, Writing – original draft, Writing – review & editing

Affiliations Centre de recherche sur le cancer, Centre de recherche du CHU de Québec-Université Laval, Québec, Canada, Département de médecine sociale et préventive, Faculté de médecine, Université Laval, Québec, Canada, Centre des Maladies du Sein, Hôpital du Saint-Sacrement, Québec, Canada
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Francine Durocher

Roles Conceptualization, Methodology, Resources, Writing – original draft, Writing – review & editing

* E-mail: francine.durocher@crchudequebec.ulaval.ca

Affiliations Centre de recherche sur le cancer, Centre de recherche du CHU de Québec-Université Laval, Québec, Canada, Département de médecine moléculaire, Faculté de médecine, Université Laval, Québec, Canada

http://orcid.org/0000-0001-8012-4641

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Trastuzumab effects depend on HER2 phosphorylation in HER2-negative breast cancer cell lines

Anna Burguin,
Daniela Furrer,
Geneviève Ouellette,
Simon Jacob,
Caroline Diorio,
Francine Durocher

Published: June 25, 2020
https://doi.org/10.1371/journal.pone.0234991

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Breast cancer
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Phosphorylation
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Cancer treatment
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Membrane staining
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BT474 cells
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Immunohistochemistry techniques
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