A novel condition of mild electrical stimulation exerts immunosuppression via hydrogen peroxide production that controls multiple signaling pathway

Mariam Piruzyan; Ihori Shitanda; Yuichiro Shimauchi; Go Okita; Yu Tsurekawa; Masataka Moriuchi; Yoshio Nakano; Keisuke Teramoto; Mary Ann Suico; Tsuyoshi Shuto; Hirofumi Kai

doi:10.1371/journal.pone.0234867

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Open Access

Peer-reviewed

Research Article

A novel condition of mild electrical stimulation exerts immunosuppression via hydrogen peroxide production that controls multiple signaling pathway

Mariam Piruzyan,

Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan, Program for Leading Graduate Schools “HIGO (Health life science: Interdisciplinary and Global Oriented) Program”, Kumamoto University, Kumamoto, Japan
⨯
Ihori Shitanda,

Roles Conceptualization, Investigation, Methodology

Affiliation Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
⨯
Yuichiro Shimauchi,

Roles Investigation, Methodology

Affiliation Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
⨯
Go Okita,

Roles Investigation, Methodology

Affiliation Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
⨯
Yu Tsurekawa,

Roles Investigation, Methodology

Affiliations Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan, Program for Leading Graduate Schools “HIGO (Health life science: Interdisciplinary and Global Oriented) Program”, Kumamoto University, Kumamoto, Japan
⨯
Masataka Moriuchi,

Roles Methodology, Software

Affiliations Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan, Program for Leading Graduate Schools “HIGO (Health life science: Interdisciplinary and Global Oriented) Program”, Kumamoto University, Kumamoto, Japan
⨯
Yoshio Nakano,

Roles Investigation, Methodology

Affiliations Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan, Program for Leading Graduate Schools “HIGO (Health life science: Interdisciplinary and Global Oriented) Program”, Kumamoto University, Kumamoto, Japan
⨯
Keisuke Teramoto,

Roles Investigation, Methodology

Affiliations Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan, Program for Leading Graduate Schools “HIGO (Health life science: Interdisciplinary and Global Oriented) Program”, Kumamoto University, Kumamoto, Japan
⨯
Mary Ann Suico,

Roles Funding acquisition, Writing – original draft, Writing – review & editing

Affiliation Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
⨯
Tsuyoshi Shuto,

Roles Project administration, Resources, Supervision

Affiliation Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
⨯
Hirofumi Kai

Roles Conceptualization, Funding acquisition, Methodology, Project administration

* E-mail: hirokai@gpo.kumamoto-u.ac.jp

Affiliations Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan, Program for Leading Graduate Schools “HIGO (Health life science: Interdisciplinary and Global Oriented) Program”, Kumamoto University, Kumamoto, Japan

http://orcid.org/0000-0001-9335-2424

⨯

A novel condition of mild electrical stimulation exerts immunosuppression via hydrogen peroxide production that controls multiple signaling pathway

Mariam Piruzyan,
Ihori Shitanda,
Yuichiro Shimauchi,
Go Okita,
Yu Tsurekawa,
Masataka Moriuchi,
Yoshio Nakano,
Keisuke Teramoto,
Mary Ann Suico,
Tsuyoshi Shuto

Published: June 22, 2020
https://doi.org/10.1371/journal.pone.0234867

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