Detection of hepatitis B virus pre-S mutants in plasma by a next-generation sequencing-based platform determines their patterns in liver tissues

• Chiao-Fang Teng ,

  Roles Funding acquisition, Investigation, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: chiaofangteng@gmail.com (C-FT); suihjen0704@mail.stust.edu.tw (I-JS); longbin.cmuh@gmail.com (L-BJ)

  Affiliations Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, Organ Transplantation Center, China Medical University Hospital, Taichung, Taiwan, Research Center for Cancer Biology, China Medical University, Taichung, Taiwan

  ⨯
• Hung-Wen Tsai,

  Roles Investigation, Methodology

  Affiliation Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan

  ⨯
• Tsai-Chung Li,

  Roles Formal analysis, Investigation

  Affiliations Department of Public Health, College of Public Health, China Medical University, Taichung, Taiwan, Department of Healthcare Administration, College of Medical and Health Science, Asia University, Taichung, Taiwan

  ⨯
• Ting Wang,

  Roles Investigation

  Affiliation Organ Transplantation Center, China Medical University Hospital, Taichung, Taiwan

  ⨯
• John Wang,

  Roles Investigation

  Affiliation Department of Pathology, China Medical University Hospital, Taichung, Taiwan

  ⨯
• Woei-Cherng Shyu,

  Roles Investigation

  Affiliations Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, Department of Occupational Therapy, Asia University, Taichung, Taiwan, Department of Neurology, China Medical University Hospital, Taichung, Taiwan, Translational Medicine Research Center, China Medical University Hospital, Taichung, Taiwan

  ⨯
• Han-Chieh Wu,

  Roles Investigation

  Affiliation National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Taiwan

  ⨯
• Ih-Jen Su ,

  Roles Conceptualization, Supervision

  * E-mail: chiaofangteng@gmail.com (C-FT); suihjen0704@mail.stust.edu.tw (I-JS); longbin.cmuh@gmail.com (L-BJ)

  Affiliation Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan, Taiwan

  ⨯
• Long-Bin Jeng

  Roles Conceptualization, Supervision

  * E-mail: chiaofangteng@gmail.com (C-FT); suihjen0704@mail.stust.edu.tw (I-JS); longbin.cmuh@gmail.com (L-BJ)

  Affiliation Organ Transplantation Center, China Medical University Hospital, Taichung, Taiwan

  http://orcid.org/0000-0002-4588-2268

  ⨯