The function of a heterozygous p53 mutation in a Li-Fraumeni syndrome patient

Yang Li; Ting Li; Yuejia Tang; Zhiyan Zhan; Lixia Ding; Lili Song; Tingting Yu; Yi Yang; Jing Ma; Yingwen Zhang; Ying Zhou; Song Gu; Min Xu; Yijin Gao; Yanxin Li

doi:10.1371/journal.pone.0234262

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Open Access

Peer-reviewed

Research Article

The function of a heterozygous p53 mutation in a Li-Fraumeni syndrome patient

Yang Li ,

Contributed equally to this work with: Yang Li, Ting Li, Yuejia Tang

Roles Data curation, Writing – original draft, Writing – review & editing

Affiliation Department of Hematology & Oncology, Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Ting Li ,

Contributed equally to this work with: Yang Li, Ting Li, Yuejia Tang

Roles Data curation, Writing – original draft

Affiliation Department of Hematology & Oncology, Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Yuejia Tang ,

Contributed equally to this work with: Yang Li, Ting Li, Yuejia Tang

Roles Data curation

Affiliation Department of Hematology & Oncology, Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Zhiyan Zhan,

Roles Data curation

Affiliation Department of Hematology & Oncology, Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Lixia Ding,

Roles Data curation

Affiliation Department of Hematology & Oncology, Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Lili Song,

Roles Data curation

Affiliation Department of Hematology & Oncology, Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Tingting Yu,

Roles Data curation

Affiliation Molecular Biological Diagnostic Laboratory, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Yi Yang,

Roles Data curation

Affiliation Department of Hematology & Oncology, Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Jing Ma,

Roles Data curation

Affiliation Department of Pathology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Yingwen Zhang,

Roles Data curation

Affiliation Department of Hematology & Oncology, Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Ying Zhou,

Roles Data curation

Affiliation Department of Radiology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Song Gu,

Roles Data curation

Affiliation Department of General Surgery/Surgical Oncology Center, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Min Xu ,

Roles Data curation

* E-mail: liyanxin@scmc.com.cn (YL); gaoyijin@scmc.com.cn (YG); xumin@scmc.com.cn (MX)

Affiliation Department of General Surgery/Surgical Oncology Center, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Yijin Gao ,

Roles Data curation

* E-mail: liyanxin@scmc.com.cn (YL); gaoyijin@scmc.com.cn (YG); xumin@scmc.com.cn (MX)

Affiliation Department of Hematology & Oncology, Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Yanxin Li

Roles Conceptualization, Funding acquisition, Supervision

* E-mail: liyanxin@scmc.com.cn (YL); gaoyijin@scmc.com.cn (YG); xumin@scmc.com.cn (MX)

Affiliation Department of Hematology & Oncology, Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China

http://orcid.org/0000-0003-1055-5029

⨯

The function of a heterozygous p53 mutation in a Li-Fraumeni syndrome patient

Yang Li,
Ting Li,
Yuejia Tang,
Zhiyan Zhan,
Lixia Ding,
Lili Song,
Tingting Yu,
Yi Yang,
Jing Ma,
Yingwen Zhang

Published: June 9, 2020
https://doi.org/10.1371/journal.pone.0234262

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