Evaluation of the preclinical analgesic efficacy of naturally derived, orally administered oil forms of Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), and their 1:1 combination

• Katja Linher-Melville,

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Michael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, Ontario, Canada, Department of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

  http://orcid.org/0000-0001-8243-0212

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• Yong Fang Zhu,

  Roles Methodology, Writing – review & editing

  Affiliations Michael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, Ontario, Canada, Department of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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• Jesse Sidhu,

  Roles Methodology, Validation, Writing – review & editing

  Affiliation Department of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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• Natalka Parzei,

  Roles Methodology, Writing – review & editing

  Affiliation Department of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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• Ayesha Shahid,

  Roles Methodology

  Affiliation Department of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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• Gireesh Seesankar,

  Roles Methodology

  Affiliation Department of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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• Danny Ma,

  Roles Methodology

  Affiliation Department of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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• Zhi Wang,

  Roles Methodology

  Affiliation Department of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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• Natalie Zacal,

  Roles Methodology

  Affiliation Department of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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• Manu Sharma,

  Roles Methodology

  Affiliation Department of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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• Vikas Parihar,

  Roles Conceptualization

  Affiliation Michael G. DeGroote Pain Clinic, McMaster University Medical Centre, Hamilton, Ontario, Canada

  http://orcid.org/0000-0002-3369-5908

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• Ramesh Zacharias,

  Roles Conceptualization, Funding acquisition

  Affiliation Michael G. DeGroote Pain Clinic, McMaster University Medical Centre, Hamilton, Ontario, Canada

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• Gurmit Singh

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: gsingh@mcmaster.ca

  Affiliations Michael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, Ontario, Canada, Department of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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