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Open Access
Peer-reviewed
Research Article
IMRAS—A clinical trial of mosquito-bite immunization with live, radiation-attenuated P. falciparum sporozoites: Impact of immunization parameters on protective efficacy and generation of a repository of immunologic reagents
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Bradley Hickey,
Roles Conceptualization, Investigation, Methodology, Project administration, Writing – review & editing
Affiliation Malaria Department, Naval Medical Research Center, Silver Spring, MD, United States of America
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Nimfa Teneza-Mora,
Roles Investigation, Project administration, Writing – original draft
Affiliation Malaria Department, Naval Medical Research Center, Silver Spring, MD, United States of America
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Joanne Lumsden,
Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft
Affiliations Malaria Department, Naval Medical Research Center, Silver Spring, MD, United States of America, Henry M. Jackson Foundation, Bethesda, MD, United States of America
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Sharina Reyes,
Roles Investigation, Project administration, Writing – review & editing
Affiliations Malaria Department, Naval Medical Research Center, Silver Spring, MD, United States of America, Henry M. Jackson Foundation, Bethesda, MD, United States of America
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Martha Sedegah,
Roles Formal analysis, Investigation, Supervision, Validation, Visualization, Writing – review & editing
Affiliation Malaria Department, Naval Medical Research Center, Silver Spring, MD, United States of America
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Lindsey Garver,
Roles Investigation, Project administration, Supervision
Affiliation Walter Reed Army Institute of Research, Silver Spring, MD, United States of America
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Michael R. Hollingdale ,
Roles Formal analysis, Visualization, Writing – original draft, Writing – review & editing
* E-mail: mikedc110@gmail.com
Affiliations Malaria Department, Naval Medical Research Center, Silver Spring, MD, United States of America, Henry M. Jackson Foundation, Bethesda, MD, United States of America
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Jo Glenna Banania,
Roles Investigation
Affiliations Malaria Department, Naval Medical Research Center, Silver Spring, MD, United States of America, Henry M. Jackson Foundation, Bethesda, MD, United States of America
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Harini Ganeshan,
Roles Investigation, Validation
Affiliations Malaria Department, Naval Medical Research Center, Silver Spring, MD, United States of America, Henry M. Jackson Foundation, Bethesda, MD, United States of America
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Megan Dowler,
Roles Investigation
Affiliation Walter Reed Army Institute of Research, Silver Spring, MD, United States of America
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Anatalio Reyes,
Roles Investigation, Validation
Affiliations Malaria Department, Naval Medical Research Center, Silver Spring, MD, United States of America, Henry M. Jackson Foundation, Bethesda, MD, United States of America
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Cindy Tamminga,
Roles Investigation
Affiliation Malaria Department, Naval Medical Research Center, Silver Spring, MD, United States of America
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Alexandra Singer,
Roles Investigation
Affiliation Malaria Department, Naval Medical Research Center, Silver Spring, MD, United States of America
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Alicia Simmons,
Roles Investigation
Affiliations Malaria Department, Naval Medical Research Center, Silver Spring, MD, United States of America, Henry M. Jackson Foundation, Bethesda, MD, United States of America
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Maria Belmonte,
Roles Investigation, Validation, Visualization
Affiliations Malaria Department, Naval Medical Research Center, Silver Spring, MD, United States of America, Henry M. Jackson Foundation, Bethesda, MD, United States of America
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Arnel Belmonte,
Roles Investigation
Affiliations Malaria Department, Naval Medical Research Center, Silver Spring, MD, United States of America, Henry M. Jackson Foundation, Bethesda, MD, United States of America
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Jun Huang,
Roles Investigation
Affiliations Malaria Department, Naval Medical Research Center, Silver Spring, MD, United States of America, Henry M. Jackson Foundation, Bethesda, MD, United States of America
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Sandra Inoue,
Roles Investigation
Affiliations Malaria Department, Naval Medical Research Center, Silver Spring, MD, United States of America, Henry M. Jackson Foundation, Bethesda, MD, United States of America
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Rachel Velasco,
Roles Investigation
Affiliations Malaria Department, Naval Medical Research Center, Silver Spring, MD, United States of America, Henry M. Jackson Foundation, Bethesda, MD, United States of America
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Steve Abot,
Roles Investigation
Affiliations Malaria Department, Naval Medical Research Center, Silver Spring, MD, United States of America, Henry M. Jackson Foundation, Bethesda, MD, United States of America
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Carlos S. Vasquez,
Roles Investigation, Software
Affiliations Malaria Department, Naval Medical Research Center, Silver Spring, MD, United States of America, Henry M. Jackson Foundation, Bethesda, MD, United States of America
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Ivelese Guzman,
Roles Investigation
Affiliations Malaria Department, Naval Medical Research Center, Silver Spring, MD, United States of America, Henry M. Jackson Foundation, Bethesda, MD, United States of America
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Mimi Wong,
Roles Data curation, Software, Validation, Writing – review & editing
Affiliations Malaria Department, Naval Medical Research Center, Silver Spring, MD, United States of America, Henry M. Jackson Foundation, Bethesda, MD, United States of America
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Patrick Twomey,
Roles Investigation, Supervision
Affiliation Walter Reed Army Institute of Research, Silver Spring, MD, United States of America
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Mariusz Wojnarski,
Roles Investigation, Supervision
Affiliation Walter Reed Army Institute of Research, Silver Spring, MD, United States of America
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James Moon,
Roles Investigation, Supervision
Affiliation Walter Reed Army Institute of Research, Silver Spring, MD, United States of America
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Yolanda Alcorta,
Roles Investigation
Affiliations Malaria Department, Naval Medical Research Center, Silver Spring, MD, United States of America, Henry M. Jackson Foundation, Bethesda, MD, United States of America
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Santina Maiolatesi,
Roles Project administration
Affiliations Malaria Department, Naval Medical Research Center, Silver Spring, MD, United States of America, Henry M. Jackson Foundation, Bethesda, MD, United States of America
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Michele Spring,
Roles Investigation, Supervision
Affiliations Henry M. Jackson Foundation, Bethesda, MD, United States of America, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America
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Silas Davidson,
Roles Investigation, Supervision
Affiliation Walter Reed Army Institute of Research, Silver Spring, MD, United States of America
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Sidhartha Chaudhury,
Roles Formal analysis, Writing – review & editing
Affiliations Walter Reed Army Institute of Research, Silver Spring, MD, United States of America, Biotechnology HPC Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Development Command, Frederick, MD, United States of America
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Eileen Villasante,
Roles Funding acquisition, Project administration, Resources, Supervision
Affiliation Malaria Department, Naval Medical Research Center, Silver Spring, MD, United States of America
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Thomas L. Richie ,
Contributed equally to this work with: Thomas L. Richie, Judith E. Epstein
Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Visualization, Writing – original draft, Writing – review & editing
Current address: Sanaria Inc., Rockville, MD, United States of America
Affiliations Malaria Department, Naval Medical Research Center, Silver Spring, MD, United States of America, Malaria Department, Naval Medical Research Center, Silver Spring, MD, United States of America
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Judith E. Epstein
Contributed equally to this work with: Thomas L. Richie, Judith E. Epstein
Roles Conceptualization, Formal analysis, Investigation, Supervision, Visualization, Writing – original draft, Writing – review & editing
Affiliation Malaria Department, Naval Medical Research Center, Silver Spring, MD, United States of America
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IMRAS—A clinical trial of mosquito-bite immunization with live, radiation-attenuated P. falciparum sporozoites: Impact of immunization parameters on protective efficacy and generation of a repository of immunologic reagents
- Bradley Hickey,
- Nimfa Teneza-Mora,
- Joanne Lumsden,
- Sharina Reyes,
- Martha Sedegah,
- Lindsey Garver,
- Michael R. Hollingdale,
- Jo Glenna Banania,
- Harini Ganeshan,
- Megan Dowler
- Published: June 17, 2020
- https://doi.org/10.1371/journal.pone.0233840