Hypomethylation of IL1RN and NFKB1 genes is linked to the dysbalance in IL1β/IL-1Ra axis in female patients with type 2 diabetes mellitus

Sona Margaryan; Eva Kriegova; Regina Fillerova; Veronika Smotkova Kraiczova; Gayane Manukyan

doi:10.1371/journal.pone.0233737

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Peer-reviewed

Research Article

Hypomethylation of IL1RN and NFKB1 genes is linked to the dysbalance in IL1β/IL-1Ra axis in female patients with type 2 diabetes mellitus

Sona Margaryan,

Roles Investigation, Methodology, Validation

Affiliations Department of Immunology, Faculty of Medicine and Dentistry, Palacký University and University Hospital Olomouc, Olomouc, Czech Republic, Russian-Armenian (Slavonic) University, Yerevan, Armenia, Institute of Molecular Biology, Laboratory of Molecular and Cellular Immunology, Yerevan, Armenia
⨯
Eva Kriegova,

Roles Data curation, Funding acquisition, Supervision, Writing – review & editing

Affiliation Department of Immunology, Faculty of Medicine and Dentistry, Palacký University and University Hospital Olomouc, Olomouc, Czech Republic
⨯
Regina Fillerova,

Roles Formal analysis, Investigation, Methodology, Software

Affiliation Department of Immunology, Faculty of Medicine and Dentistry, Palacký University and University Hospital Olomouc, Olomouc, Czech Republic
⨯
Veronika Smotkova Kraiczova,

Roles Formal analysis, Investigation, Methodology

Affiliation Department of Immunology, Faculty of Medicine and Dentistry, Palacký University and University Hospital Olomouc, Olomouc, Czech Republic
⨯
Gayane Manukyan

Roles Funding acquisition, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

* E-mail: gaya.manukyan@gmail.com, g_manukyan@mb.sci.am

Affiliations Department of Immunology, Faculty of Medicine and Dentistry, Palacký University and University Hospital Olomouc, Olomouc, Czech Republic, Russian-Armenian (Slavonic) University, Yerevan, Armenia, Institute of Molecular Biology, Laboratory of Molecular and Cellular Immunology, Yerevan, Armenia

http://orcid.org/0000-0001-7541-5743

⨯

Hypomethylation of IL1RN and NFKB1 genes is linked to the dysbalance in IL1β/IL-1Ra axis in female patients with type 2 diabetes mellitus

Sona Margaryan,
Eva Kriegova,
Regina Fillerova,
Veronika Smotkova Kraiczova,
Gayane Manukyan

Published: May 29, 2020
https://doi.org/10.1371/journal.pone.0233737

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