Active Notch signaling is required for arm regeneration in a brittle star

Vladimir Mashanov; Jennifer Akiona; Maleana Khoury; Jacob Ferrier; Robert Reid; Denis Jacob Machado; Olga Zueva; Daniel Janies

doi:10.1371/journal.pone.0232981

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Open Access

Peer-reviewed

Research Article

Active Notch signaling is required for arm regeneration in a brittle star

Vladimir Mashanov ,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: vmashano@wakehealth.edu

Affiliations Department of Biology, University of North Florida, Jacksonville, FL, United states of America, Wake Forest Institute for Regenerative Medicine, Winston Salem, NC, United states of America

http://orcid.org/0000-0001-6875-7518

⨯
Jennifer Akiona,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Biology, University of North Florida, Jacksonville, FL, United states of America

http://orcid.org/0000-0002-6420-5940

⨯
Maleana Khoury,

Roles Formal analysis, Investigation

Affiliation Department of Biology, University of North Florida, Jacksonville, FL, United states of America
⨯
Jacob Ferrier,

Roles Data curation, Methodology

Affiliation University of North Carolina at Charlotte, Charlotte, NC, United states of America

http://orcid.org/0000-0002-4173-1040

⨯
Robert Reid,

Roles Data curation, Formal analysis, Investigation, Methodology, Software

Affiliation University of North Carolina at Charlotte, Charlotte, NC, United states of America
⨯
Denis Jacob Machado,

Roles Investigation, Methodology, Software, Validation, Writing – original draft, Writing – review & editing

Affiliation University of North Carolina at Charlotte, Charlotte, NC, United states of America

http://orcid.org/0000-0001-9858-4515

⨯
Olga Zueva,

Roles Conceptualization, Investigation, Methodology

Affiliation Department of Biology, University of North Florida, Jacksonville, FL, United states of America
⨯
Daniel Janies

Roles Data curation, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliation University of North Carolina at Charlotte, Charlotte, NC, United states of America
⨯

Active Notch signaling is required for arm regeneration in a brittle star

Vladimir Mashanov,
Jennifer Akiona,
Maleana Khoury,
Jacob Ferrier,
Robert Reid,
Denis Jacob Machado,
Olga Zueva,
Daniel Janies

Published: May 12, 2020
https://doi.org/10.1371/journal.pone.0232981
See the preprint

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Notch signaling
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Echinoderms
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Limb regeneration
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Transcriptome analysis
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DNA-binding proteins
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Gene expression
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Gene regulation
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Immune response
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