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Open Access
Peer-reviewed
Research Article
Modeling and mitigation of high-concentration antibody viscosity through structure-based computer-aided protein design
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James R. Apgar ,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: james.r.apgar@pfizer.com
Affiliation BioMedicine Design, Pfizer Inc, Cambridge, Massachusetts, United States of America
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Amy S. P. Tam,
Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing
Affiliation BioMedicine Design, Pfizer Inc, Cambridge, Massachusetts, United States of America
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Rhady Sorm,
Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing
Affiliation BioMedicine Design, Pfizer Inc, Cambridge, Massachusetts, United States of America
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Sybille Moesta,
Roles Data curation, Investigation, Methodology, Writing – review & editing
Current address: St. George’s University School of Medicine, Grenada, West Indies
Affiliation BioMedicine Design, Pfizer Inc, Cambridge, Massachusetts, United States of America
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Amy C. King,
Roles Data curation, Formal analysis, Methodology, Writing – review & editing
Affiliation BioMedicine Design, Pfizer Inc, Cambridge, Massachusetts, United States of America
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Han Yang,
Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing
Affiliation BioMedicine Design, Pfizer Inc, Cambridge, Massachusetts, United States of America
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Kerry Kelleher,
Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing
Affiliation BioMedicine Design, Pfizer Inc, Cambridge, Massachusetts, United States of America
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Denise Murphy,
Roles Investigation, Methodology, Resources, Writing – review & editing
Affiliation BioMedicine Design, Pfizer Inc, Cambridge, Massachusetts, United States of America
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Aaron M. D’Antona,
Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing
Affiliation BioMedicine Design, Pfizer Inc, Cambridge, Massachusetts, United States of America
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Guoying Yan,
Roles Formal analysis, Investigation, Methodology, Resources, Writing – review & editing
Affiliation BioMedicine Design, Pfizer Inc, Cambridge, Massachusetts, United States of America
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Xiaotian Zhong,
Roles Investigation, Methodology, Resources, Supervision, Writing – review & editing
Affiliation BioMedicine Design, Pfizer Inc, Cambridge, Massachusetts, United States of America
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Linette Rodriguez,
Roles Investigation, Methodology, Resources, Writing – review & editing
Affiliation BioMedicine Design, Pfizer Inc, Cambridge, Massachusetts, United States of America
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Weijun Ma,
Roles Investigation, Methodology, Resources, Writing – review & editing
Affiliation BioMedicine Design, Pfizer Inc, Cambridge, Massachusetts, United States of America
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Darren E. Ferguson,
Roles Investigation, Methodology, Resources, Writing – review & editing
Affiliation BioMedicine Design, Pfizer Inc, Cambridge, Massachusetts, United States of America
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Gregory J. Carven,
Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing
Current address: Scholar Rock, Cambridge, Massachusetts, United States of America
Affiliation BioMedicine Design, Pfizer Inc, Cambridge, Massachusetts, United States of America
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Eric M. Bennett,
Roles Conceptualization, Methodology, Resources, Software, Supervision, Writing – review & editing
Affiliation BioMedicine Design, Pfizer Inc, Cambridge, Massachusetts, United States of America
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Laura Lin
Roles Conceptualization, Resources, Supervision, Writing – review & editing
Affiliation BioMedicine Design, Pfizer Inc, Cambridge, Massachusetts, United States of America
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Modeling and mitigation of high-concentration antibody viscosity through structure-based computer-aided protein design
- James R. Apgar,
- Amy S. P. Tam,
- Rhady Sorm,
- Sybille Moesta,
- Amy C. King,
- Han Yang,
- Kerry Kelleher,
- Denise Murphy,
- Aaron M. D’Antona,
- Guoying Yan
- Published: May 7, 2020
- https://doi.org/10.1371/journal.pone.0232713