Computed tomography-derived radiomic signature of head and neck squamous cell carcinoma (peri)tumoral tissue for the prediction of locoregional recurrence and distant metastasis after concurrent chemo-radiotherapy

• Simon Keek ,

  Contributed equally to this work with: Simon Keek, Sebastian Sanduleanu, Frank Hoebers, Philippe Lambin

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Validation, Writing – original draft, Writing – review & editing

  Affiliation The D-lab, Department of Precision Medicine, GROW – School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands

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• Sebastian Sanduleanu ,

  Contributed equally to this work with: Simon Keek, Sebastian Sanduleanu, Frank Hoebers, Philippe Lambin

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Validation, Writing – original draft, Writing – review & editing

  * E-mail: s.sanduleanu@maastrichtuniversity.nl

  Affiliation The D-lab, Department of Precision Medicine, GROW – School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands

  http://orcid.org/0000-0002-5961-9807

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• Frederik Wesseling,

  Roles Conceptualization, Data curation, Investigation, Software, Writing – original draft, Writing – review & editing

  Affiliation Department of Radiation Oncology (MAASTRO), GROW – School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands

  http://orcid.org/0000-0003-2208-3778

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• Reinout de Roest,

  Roles Conceptualization, Data curation, Formal analysis, Project administration, Software, Writing – original draft, Writing – review & editing

  Affiliation Amsterdam UMC, Vrije Universiteit Amsterdam, Otolaryngology / Head and Neck Surgery, Cancer Center Amsterdam, The Netherlands

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• Michiel van den Brekel,

  Roles Data curation, Formal analysis, Resources, Writing – original draft, Writing – review & editing

  Affiliations Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands, Department of Oral and Maxillofacial Surgery, Academic Medical Center, Amsterdam, The Netherlands

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• Martijn van der Heijden,

  Roles Conceptualization, Formal analysis, Investigation, Project administration, Writing – original draft, Writing – review & editing

  Affiliations Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands, Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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• Conchita Vens,

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands, Department of radiation oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

  http://orcid.org/0000-0002-8608-7236

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• Calareso Giuseppina,

  Roles Investigation, Project administration, Resources, Writing – original draft, Writing – review & editing

  Affiliation Istituto nazionale dei tumori, Department of Radiology, Milan, Italy

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• Lisa Licitra,

  Roles Data curation, Methodology, Project administration, Writing – original draft, Writing – review & editing

  Affiliations Fondazione IRCCS Istituto Nazionale dei Tumori, Head and Neck Medical Oncology Department, Milan, Italy, University of Milan, Department of Oncology and Hematology-Oncology, Milan, Italy

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• Kathrin Scheckenbach,

  Roles Data curation, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

  Affiliation Dept. of Otorhinolaryngology, Head and Neck Surgery, Heinrich-Heine-University, Düsseldorf, Germany

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• Marije Vergeer,

  Roles Data curation, Project administration, Resources, Writing – original draft, Writing – review & editing

  Affiliation Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Radiation Oncology Amsterdam, The Netherlands

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• C. René Leemans,

  Roles Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Amsterdam UMC, Vrije Universiteit Amsterdam, Otolaryngology / Head and Neck Surgery, Cancer Center Amsterdam, The Netherlands

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• Ruud H Brakenhoff,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Amsterdam UMC, Vrije Universiteit Amsterdam, Otolaryngology / Head and Neck Surgery, Cancer Center Amsterdam, The Netherlands

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• Irene Nauta,

  Roles Data curation, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

  Affiliation Amsterdam UMC, Vrije Universiteit Amsterdam, Otolaryngology / Head and Neck Surgery, Cancer Center Amsterdam, The Netherlands

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• Stefano Cavalieri,

  Roles Data curation, Supervision, Writing – review & editing

  Affiliation Istituto nazionale dei tumori, Department of Radiology, Milan, Italy

  http://orcid.org/0000-0003-1294-6859

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• Henry C. Woodruff,

  Roles Conceptualization, Methodology, Software, Supervision, Writing – original draft, Writing – review & editing

  Affiliations The D-lab, Department of Precision Medicine, GROW – School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands, Department of Radiology and Nuclear Medicine, GROW – School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands

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• Tito Poli,

  Roles Conceptualization, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

  Affiliation University of Parma, Department of Surgical Sciences, Parma, Italy

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• Ralph Leijenaar,

  Roles Conceptualization, Project administration, Writing – original draft, Writing – review & editing

  Affiliation Department of Radiation Oncology (MAASTRO), GROW – School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands

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• Frank Hoebers ,

  Contributed equally to this work with: Simon Keek, Sebastian Sanduleanu, Frank Hoebers, Philippe Lambin

  Roles Conceptualization, Funding acquisition, Project administration, Writing – original draft, Writing – review & editing

  Affiliation Department of Radiation Oncology (MAASTRO), GROW – School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands

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•  [ ... ],
• Philippe Lambin

  Contributed equally to this work with: Simon Keek, Sebastian Sanduleanu, Frank Hoebers, Philippe Lambin

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing

  Affiliations The D-lab, Department of Precision Medicine, GROW – School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands, Department of Radiology and Nuclear Medicine, GROW – School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands

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