Upshaw-Schulman syndrome-associated ADAMTS13 variants possess proteolytic activity at the surface of endothelial cells and in simulated circulation

• Anton Letzer ,

  Contributed equally to this work with: Anton Letzer, Katja Lehmann

  Roles Formal analysis, Investigation

  Affiliation Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  http://orcid.org/0000-0001-7446-2687

  ⨯
• Katja Lehmann ,

  Contributed equally to this work with: Anton Letzer, Katja Lehmann

  Roles Formal analysis, Investigation

  Affiliation Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  ⨯
• Christian Mess,

  Roles Formal analysis

  Affiliation Department of Dermatology and Venerology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  ⨯
• Gesa König,

  Roles Investigation

  Affiliation Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  ⨯
• Tobias Obser,

  Roles Investigation

  Affiliation Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  ⨯
• Sven Peine,

  Roles Resources

  Affiliation Institute for Transfusion Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  ⨯
• Sonja Schneppenheim,

  Roles Investigation, Methodology

  Affiliation Haemostaseology, MEDILYS Laborgesellschaft mbH, Hamburg, Germany

  ⨯
• Ulrich Budde,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Haemostaseology, MEDILYS Laborgesellschaft mbH, Hamburg, Germany

  ⨯
• Stefan W. Schneider,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Dermatology and Venerology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  ⨯
• Reinhard Schneppenheim,

  Roles Resources, Writing – review & editing

  Affiliation Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  ⨯
• Maria A. Brehm

  Roles Investigation, Methodology, Supervision, Writing – original draft

  * E-mail: m.brehm@uke.de

  Affiliation Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  http://orcid.org/0000-0003-0416-8233

  ⨯