An immunohistochemical prostate cell identification key indicates that aging shifts procollagen 1A1 production from myofibroblasts to fibroblasts in dogs prone to prostate-related urinary dysfunction

• Hannah Ruetten ,

  Contributed equally to this work with: Hannah Ruetten, Clara Cole, Marlyse Wehber

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Comparative Biomedical Sciences, School of Veterinary Medicine, University of Wisconsin- Madison, Madison, Wisconsin, United States of America, George M. O’Brien Benign Urology Center, University of Wisconsin- Madison, Madison, Wisconsin, United States of America

  http://orcid.org/0000-0001-6263-6221

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• Clara Cole ,

  Contributed equally to this work with: Hannah Ruetten, Clara Cole, Marlyse Wehber

  Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Comparative Biomedical Sciences, School of Veterinary Medicine, University of Wisconsin- Madison, Madison, Wisconsin, United States of America, George M. O’Brien Benign Urology Center, University of Wisconsin- Madison, Madison, Wisconsin, United States of America

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• Marlyse Wehber ,

  Contributed equally to this work with: Hannah Ruetten, Clara Cole, Marlyse Wehber

  Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Comparative Biomedical Sciences, School of Veterinary Medicine, University of Wisconsin- Madison, Madison, Wisconsin, United States of America, George M. O’Brien Benign Urology Center, University of Wisconsin- Madison, Madison, Wisconsin, United States of America

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• Kyle A. Wegner,

  Roles Conceptualization, Methodology, Resources, Writing – review & editing

  Affiliations George M. O’Brien Benign Urology Center, University of Wisconsin- Madison, Madison, Wisconsin, United States of America, Molecular and Environmental Toxicology Center, School of Medicine and Public Health, University of Wisconsin- Madison, Madison, Wisconsin, United States of America

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• Nicholas M. Girardi,

  Roles Formal analysis, Writing – review & editing

  Affiliations George M. O’Brien Benign Urology Center, University of Wisconsin- Madison, Madison, Wisconsin, United States of America, Molecular and Environmental Toxicology Center, School of Medicine and Public Health, University of Wisconsin- Madison, Madison, Wisconsin, United States of America

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• Nelson T. Peterson,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliations George M. O’Brien Benign Urology Center, University of Wisconsin- Madison, Madison, Wisconsin, United States of America, Molecular and Environmental Toxicology Center, School of Medicine and Public Health, University of Wisconsin- Madison, Madison, Wisconsin, United States of America

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• Brandon R. Scharpf,

  Roles Data curation, Writing – review & editing

  Affiliations George M. O’Brien Benign Urology Center, University of Wisconsin- Madison, Madison, Wisconsin, United States of America, Molecular and Environmental Toxicology Center, School of Medicine and Public Health, University of Wisconsin- Madison, Madison, Wisconsin, United States of America

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• Michael F. Romero,

  Roles Resources, Writing – review & editing

  Affiliation Physiology and Biomedical Engineering and Nephrology and Hypertension, George M. O’Brien Urology Research Center, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, United States of America

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• Michael W. Wood,

  Roles Resources, Writing – review & editing

  Affiliation Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin- Madison, Madison, Wisconsin, United States of America

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• Sara A. Colopy,

  Roles Resources, Writing – review & editing

  Affiliation Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin- Madison, Madison, Wisconsin, United States of America

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• Dale E. Bjorling,

  Roles Supervision, Writing – review & editing

  Affiliation Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin- Madison, Madison, Wisconsin, United States of America

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• Chad M. Vezina

  Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: cmvezina@wisc.edu

  Affiliations Department of Comparative Biomedical Sciences, School of Veterinary Medicine, University of Wisconsin- Madison, Madison, Wisconsin, United States of America, George M. O’Brien Benign Urology Center, University of Wisconsin- Madison, Madison, Wisconsin, United States of America, Molecular and Environmental Toxicology Center, School of Medicine and Public Health, University of Wisconsin- Madison, Madison, Wisconsin, United States of America

  http://orcid.org/0000-0001-7058-5399

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