TGF-beta and TNF-alpha cooperatively induce mesenchymal transition of lymphatic endothelial cells via activation of Activin signals

• Yasuhiro Yoshimatsu ,

  Contributed equally to this work with: Yasuhiro Yoshimatsu, Shiori Kimuro

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliations Department of Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan, Division of Pharmacology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan

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• Shiori Kimuro ,

  Contributed equally to this work with: Yasuhiro Yoshimatsu, Shiori Kimuro

  Roles Data curation, Investigation, Validation, Writing – review & editing

  Affiliation Department of Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan

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• Joris Pauty,

  Roles Data curation, Investigation, Validation, Writing – review & editing

  Affiliation Institute of Industrial Science, The University of Tokyo, Tokyo, Japan

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• Kazuki Takagaki,

  Roles Data curation, Investigation, Validation, Writing – review & editing

  Affiliation Shiseido Global Innovation Center, Yokohama, Japan

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• Sanae Nomiyama,

  Roles Data curation, Investigation, Validation, Writing – review & editing

  Affiliation Shiseido Global Innovation Center, Yokohama, Japan

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• Akihiko Inagawa,

  Roles Data curation, Investigation, Validation, Writing – review & editing

  Affiliation Department of Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan

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• Kentaro Maeda,

  Roles Data curation, Investigation, Validation, Writing – review & editing

  Affiliation Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan

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• Katarzyna A. Podyma-Inoue,

  Roles Data curation, Investigation, Validation, Writing – review & editing

  Affiliation Department of Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan

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• Kentaro Kajiya,

  Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation Shiseido Global Innovation Center, Yokohama, Japan

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• Yukiko T. Matsunaga,

  Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation Institute of Industrial Science, The University of Tokyo, Tokyo, Japan

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• Tetsuro Watabe

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: t-watabe@umin.ac.jp

  Affiliations Department of Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan

  http://orcid.org/0000-0001-5836-1309

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