Treatment of cancer cells with Lapatinib negatively regulates general translation and induces stress granules formation

Pauline Adjibade; Bryan Simoneau; Nassim Ledoux; William-Naud Gauthier; Melisse Nkurunziza; Edouard W. Khandjian; Rachid Mazroui

doi:10.1371/journal.pone.0231894

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Open Access

Peer-reviewed

Research Article

Treatment of cancer cells with Lapatinib negatively regulates general translation and induces stress granules formation

Pauline Adjibade,

Roles Formal analysis, Methodology, Validation, Writing – original draft

Affiliation Département de Biologie Moléculaire, Biochimie Médicale et Pathologie, Centre de Recherche en Cancérologie, Centre de Recherche du CHU de Québec, Faculté de Médecine, Université Laval, Québec, Parti Québécois, Canada
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Bryan Simoneau,

Roles Data curation, Investigation, Methodology

Affiliation Département de Biologie Moléculaire, Biochimie Médicale et Pathologie, Centre de Recherche en Cancérologie, Centre de Recherche du CHU de Québec, Faculté de Médecine, Université Laval, Québec, Parti Québécois, Canada
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Nassim Ledoux,

Roles Investigation

Affiliation Département de Biologie Moléculaire, Biochimie Médicale et Pathologie, Centre de Recherche en Cancérologie, Centre de Recherche du CHU de Québec, Faculté de Médecine, Université Laval, Québec, Parti Québécois, Canada
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William-Naud Gauthier,

Roles Data curation, Methodology

Affiliation Département de Biologie Moléculaire, Biochimie Médicale et Pathologie, Centre de Recherche en Cancérologie, Centre de Recherche du CHU de Québec, Faculté de Médecine, Université Laval, Québec, Parti Québécois, Canada
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Melisse Nkurunziza,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Département de Biologie Moléculaire, Biochimie Médicale et Pathologie, Centre de Recherche en Cancérologie, Centre de Recherche du CHU de Québec, Faculté de Médecine, Université Laval, Québec, Parti Québécois, Canada
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Edouard W. Khandjian,

Roles Resources

Affiliation Département de Psychiatrie et de Neurosciences, Centre de Recherche, Institut Universitaire en Santé mentale de Québec, Faculté de Médecine, Université Laval, Québec, Parti Québécois, Canada
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Rachid Mazroui

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

* E-mail: Rachid.Mazroui@crchudequebec.ulaval.ca

Affiliation Département de Biologie Moléculaire, Biochimie Médicale et Pathologie, Centre de Recherche en Cancérologie, Centre de Recherche du CHU de Québec, Faculté de Médecine, Université Laval, Québec, Parti Québécois, Canada

http://orcid.org/0000-0001-7796-2740

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Treatment of cancer cells with Lapatinib negatively regulates general translation and induces stress granules formation

Pauline Adjibade,
Bryan Simoneau,
Nassim Ledoux,
William-Naud Gauthier,
Melisse Nkurunziza,
Edouard W. Khandjian,
Rachid Mazroui

Published: May 4, 2020
https://doi.org/10.1371/journal.pone.0231894

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Cancer treatment
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Breast cancer
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Phosphorylation
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Drug therapy
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Immunofluorescence
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Antibody therapy
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Translation initiation
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Cell death
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