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SMOOT libraries and phage-induced directed evolution of Cas9 to engineer reduced off-target activity
- Derek Cerchione,
- Katherine Loveluck,
- Eric L. Tillotson,
- Fred Harbinski,
- Jen DaSilva,
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Chase P. Kelley,
Roles Investigation, Writing – review & editing
Affiliation Editas Medicine, Cambridge, Massachusetts, United States of America
⨯ - Elise Keston-Smith,
- Cecilia A. Fernandez,
- Vic E. Myer,
- Hariharan Jayaram,
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Barrett E. Steinberg
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Visualization, Writing – original draft, Writing – review & editing
* E-mail: barrett.steinberg@gmail.com
Affiliation Editas Medicine, Cambridge, Massachusetts, United States of America
⨯
http://orcid.org/0000-0001-5383-4701
SMOOT libraries and phage-induced directed evolution of Cas9 to engineer reduced off-target activity
- Derek Cerchione,
- Katherine Loveluck,
- Eric L. Tillotson,
- Fred Harbinski,
- Jen DaSilva,
- Chase P. Kelley,
- Elise Keston-Smith,
- Cecilia A. Fernandez,
- Vic E. Myer,
- Hariharan Jayaram
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- Published: April 16, 2020
- https://doi.org/10.1371/journal.pone.0231716