Patient-derived oral mucosa organoids as an in vitro model for methotrexate induced toxicity in pediatric acute lymphoblastic leukemia

• E. Driehuis ,

  Contributed equally to this work with: E. Driehuis, N. Oosterom

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, The Netherlands

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• N. Oosterom ,

  Contributed equally to this work with: E. Driehuis, N. Oosterom

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

  http://orcid.org/0000-0001-9871-1887

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• S. G. Heil,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Clinical Chemistry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

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• I. B. Muller,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Clinical Chemistry, Amsterdam UMC, Amsterdam, The Netherlands

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• M. Lin,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Clinical Chemistry, Amsterdam UMC, Amsterdam, The Netherlands

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• S. Kolders,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, The Netherlands

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• G. Jansen,

  Roles Conceptualization, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Amsterdam Rheumatology and Immunology Center, Department of Rheumatology, Amsterdam UMC, Amsterdam, The Netherlands

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• R. de Jonge,

  Roles Investigation, Methodology, Supervision, Validation, Writing – review & editing

  Affiliation Department of Clinical Chemistry, Amsterdam UMC, Amsterdam, The Netherlands

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• R. Pieters,

  Roles Supervision, Writing – review & editing

  Affiliation Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

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• H. Clevers,

  Roles Resources, Supervision, Writing – review & editing

  Affiliations Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, The Netherlands, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

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• M. M. van den Heuvel-Eibrink

  Roles Conceptualization, Resources, Supervision, Writing – review & editing

  * E-mail: m.m.vandenheuvel-eibrink@prinsesmaximacentrum.nl

  Affiliation Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

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