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Open Access
Peer-reviewed
Research Article
Ototopical drops containing a novel antibacterial synthetic peptide: Safety and efficacy in adults with chronic suppurative otitis media
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Nanno F. A. W. Peek,
Roles Conceptualization, Data curation, Investigation, Project administration, Writing – original draft, Writing – review & editing
Affiliation Department of Ear Nose and Throat, Leiden University Medical Centre (LUMC), Leiden, The Netherlands
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Marja J. Nell,
Roles Conceptualization, Data curation, Investigation, Writing – review & editing
Affiliation Octoplus Technologies BV/Dr Reddy’s research and development BV, Leiden, The Netherlands
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Ronald Brand,
Roles Data curation, Formal analysis, Methodology, Writing – review & editing
Affiliation Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands
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Thekla Jansen-Werkhoven,
Roles Data curation, Formal analysis, Methodology, Project administration, Writing – review & editing
Affiliation Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands
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Ewoud J. van Hoogdalem,
Roles Conceptualization, Data curation, Project administration, Writing – review & editing
Affiliation Octoplus Technologies BV/Dr Reddy’s research and development BV, Leiden, The Netherlands
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Ruud Verrijk,
Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing
Affiliation Octoplus Technologies BV/Dr Reddy’s research and development BV, Leiden, The Netherlands
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Marcel J. Vonk,
Roles Conceptualization, Data curation, Methodology, Writing – review & editing
Affiliation Department of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands
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Amon R. Wafelman,
Roles Methodology, Validation, Writing – review & editing
Affiliation Clinical Pharmacology and Toxicology, Leiden University Medical Centre, Leiden, The Netherlands
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A. Rob P. M. Valentijn,
Roles Methodology, Validation, Writing – review & editing
Affiliation Clinical Pharmacology and Toxicology, Leiden University Medical Centre, Leiden, The Netherlands
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Johan H. M. Frijns,
Roles Conceptualization, Supervision, Validation, Writing – review & editing
Affiliation Department of Ear Nose and Throat, Leiden University Medical Centre (LUMC), Leiden, The Netherlands
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Pieter S. Hiemstra,
Roles Conceptualization, Methodology, Supervision, Writing – review & editing
Affiliation Department of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands
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Jan W. Drijfhout,
Roles Conceptualization, Methodology, Resources, Supervision, Writing – review & editing
Affiliation Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands
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Peter H. Nibbering ,
Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing
* E-mail: p.h.nibbering@lumc.nl
Affiliation Department of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands
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Jan J. Grote
Roles Conceptualization, Methodology, Supervision, Validation, Writing – review & editing
Affiliation Department of Ear Nose and Throat, Leiden University Medical Centre (LUMC), Leiden, The Netherlands
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Ototopical drops containing a novel antibacterial synthetic peptide: Safety and efficacy in adults with chronic suppurative otitis media
- Nanno F. A. W. Peek,
- Marja J. Nell,
- Ronald Brand,
- Thekla Jansen-Werkhoven,
- Ewoud J. van Hoogdalem,
- Ruud Verrijk,
- Marcel J. Vonk,
- Amon R. Wafelman,
- A. Rob P. M. Valentijn,
- Johan H. M. Frijns
![PLOS](/resource/img/logo-plos.png)
- Published: April 14, 2020
- https://doi.org/10.1371/journal.pone.0231573