Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose

• Sarah Piel ,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft

  * E-mail: sarah.piel@med.lu.se

  Affiliations Department of Clinical Sciences Lund, Mitochondrial Medicine, Lund University, Lund, Sweden, NeuroVive Pharmaceutical AB, Medicon Village, Lund, Sweden, Department of Anesthesiology and Critical Care Medicine, Center for Mitochondrial and Epigenomic Medicine, The Children’s Hospital of Philadelphia, Philadelphia, United States of America

  http://orcid.org/0000-0002-1779-3532

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• Imen Chamkha,

  Roles Data curation, Writing – review & editing

  Affiliations Department of Clinical Sciences Lund, Mitochondrial Medicine, Lund University, Lund, Sweden, NeuroVive Pharmaceutical AB, Medicon Village, Lund, Sweden

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• Adam Kozak Dehlin,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Clinical Sciences Lund, Mitochondrial Medicine, Lund University, Lund, Sweden

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• Johannes K. Ehinger,

  Roles Conceptualization, Writing – review & editing

  Affiliations Department of Clinical Sciences Lund, Mitochondrial Medicine, Lund University, Lund, Sweden, NeuroVive Pharmaceutical AB, Medicon Village, Lund, Sweden

  http://orcid.org/0000-0002-2417-5767

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• Fredrik Sjövall,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliations Department of Clinical Sciences Lund, Mitochondrial Medicine, Lund University, Lund, Sweden, Department of Clinical Sciences Lund, Skane University Hospital, Intensive Care and Perioperative Medicine, Lund University, Malmö, Sweden

  http://orcid.org/0000-0001-5612-0325

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• Eskil Elmér,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliations Department of Clinical Sciences Lund, Mitochondrial Medicine, Lund University, Lund, Sweden, NeuroVive Pharmaceutical AB, Medicon Village, Lund, Sweden, Department of Clinical Sciences Lund, Skane University Hospital, Clinical Neurophysiology, Lund University, Lund, Sweden

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• Magnus J. Hansson

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Supervision, Writing – review & editing

  Affiliations Department of Clinical Sciences Lund, Mitochondrial Medicine, Lund University, Lund, Sweden, NeuroVive Pharmaceutical AB, Medicon Village, Lund, Sweden

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