Onset hyperalgesia and offset analgesia: Transient increases or decreases of noxious thermal stimulus intensity robustly modulate subsequent perceived pain intensity

• Benedict J. Alter ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: alterbj@upmc.edu

  Current address: Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  Affiliations Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, United States of America, Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0002-0171-3411

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• Mya Sandi Aung,

  Roles Investigation

  Affiliation Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, United States of America

  https://orcid.org/0000-0002-4244-3235

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• Irina A. Strigo,

  Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing

  Affiliation San Francisco VA Health Care System & Department of Psychiatry, University of California San Francisco, San Francisco, California, United States of America

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• Howard L. Fields

  Roles Conceptualization, Funding acquisition, Methodology, Resources, Supervision, Writing – review & editing

  Affiliation Department of Neurology, University of California San Francisco, San Francisco, California, United States of America

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