Morphine exposure exacerbates HIV-1 Tat driven changes to neuroinflammatory factors in cultured astrocytes

Kenneth Chen; Thienlong Phan; Angel Lin; Luca Sardo; Anthony R. Mele; Michael R. Nonnemacher; Zachary Klase

doi:10.1371/journal.pone.0230563

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Open Access

Peer-reviewed

Research Article

Morphine exposure exacerbates HIV-1 Tat driven changes to neuroinflammatory factors in cultured astrocytes

Kenneth Chen,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft

Affiliation Department of Biological Sciences, University of the Sciences, Philadelphia, Pennsylvania, United States of America
⨯
Thienlong Phan,

Roles Investigation, Methodology

Affiliation Department of Biological Sciences, University of the Sciences, Philadelphia, Pennsylvania, United States of America
⨯
Angel Lin,

Roles Conceptualization, Investigation

Affiliation Department of Biological Sciences, University of the Sciences, Philadelphia, Pennsylvania, United States of America
⨯
Luca Sardo,

Roles Conceptualization, Investigation

Affiliations Department of Biological Sciences, University of the Sciences, Philadelphia, Pennsylvania, United States of America, Current institution – Department of Infectious Diseases and Vaccines, MRL, Merck & Co., Inc., West Point, Pennsylvania, United States of America
⨯
Anthony R. Mele,

Roles Methodology, Resources

Affiliations Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Michael R. Nonnemacher,

Roles Conceptualization, Writing – review & editing

Affiliations Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Zachary Klase

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: z.klase@usciences.edu

Affiliation Department of Biological Sciences, University of the Sciences, Philadelphia, Pennsylvania, United States of America

http://orcid.org/0000-0002-3957-6416

⨯

Morphine exposure exacerbates HIV-1 Tat driven changes to neuroinflammatory factors in cultured astrocytes

Kenneth Chen,
Thienlong Phan,
Angel Lin,
Luca Sardo,
Anthony R. Mele,
Michael R. Nonnemacher,
Zachary Klase

Published: March 25, 2020
https://doi.org/10.1371/journal.pone.0230563

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HIV-1
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Morphine
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Astrocytes
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Central nervous system
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Beta-catenin signaling
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Gene expression
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Opportunistic infections
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