The immunogenicity and protective immunity of multi-epitopes DNA prime-protein boost vaccines encoding Amastin-Kmp-11, Kmp11-Gp63 and Amastin-Gp63 against visceral leishmaniasis

Jianhui Zhang; Jinlei He; Jiao Li; Qi Zhou; Han Chen; Zhiwan Zheng; Qiwei Chen; Dali Chen; Jianping Chen

doi:10.1371/journal.pone.0230381

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Open Access

Peer-reviewed

Research Article

The immunogenicity and protective immunity of multi-epitopes DNA prime-protein boost vaccines encoding Amastin-Kmp-11, Kmp11-Gp63 and Amastin-Gp63 against visceral leishmaniasis

Jianhui Zhang ,

Contributed equally to this work with: Jianhui Zhang, Jinlei He

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Pathogenic Biology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China
⨯
Jinlei He ,

Contributed equally to this work with: Jianhui Zhang, Jinlei He

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Pathogenic Biology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China
⨯
Jiao Li,

Roles Formal analysis, Funding acquisition, Resources

Affiliation Department of Pathogenic Biology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China
⨯
Qi Zhou,

Roles Investigation

Affiliation Department of Pathogenic Biology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China
⨯
Han Chen,

Roles Investigation, Resources, Software

Affiliation Department of Pathogenic Biology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China
⨯
Zhiwan Zheng,

Roles Formal analysis, Resources

Affiliation Department of Pathogenic Biology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China
⨯
Qiwei Chen,

Roles Formal analysis, Supervision

Affiliation Department of Pathogenic Biology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China
⨯
Dali Chen,

Roles Funding acquisition, Supervision

Affiliation Department of Pathogenic Biology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China
⨯
Jianping Chen

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Validation, Visualization, Writing – review & editing

* E-mail: jpchen007@163.com

Affiliations Department of Pathogenic Biology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China, Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Sichuan University, Chengdu, Sichuan, China
⨯

The immunogenicity and protective immunity of multi-epitopes DNA prime-protein boost vaccines encoding Amastin-Kmp-11, Kmp11-Gp63 and Amastin-Gp63 against visceral leishmaniasis

Jianhui Zhang,
Jinlei He,
Jiao Li,
Qi Zhou,
Han Chen,
Zhiwan Zheng,
Qiwei Chen,
Dali Chen,
Jianping Chen

Published: March 16, 2020
https://doi.org/10.1371/journal.pone.0230381

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