Effects of intestinal flora on the pharmacokinetics and pharmacodynamics of aspirin in high-altitude hypoxia

Yuemei Sun; Juanhong Zhang; Anpeng Zhao; Wenbin Li; Qiangsheng Feng; Rong Wang

doi:10.1371/journal.pone.0230197

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Open Access

Peer-reviewed

Research Article

Effects of intestinal flora on the pharmacokinetics and pharmacodynamics of aspirin in high-altitude hypoxia

Yuemei Sun ,

Contributed equally to this work with: Yuemei Sun, Juanhong Zhang

Roles Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Key Laboratory for Prevention and Remediation of Plateau Environmental Damage, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Lanzhou, China

http://orcid.org/0000-0002-1629-7529

⨯
Juanhong Zhang ,

Contributed equally to this work with: Yuemei Sun, Juanhong Zhang

Roles Conceptualization, Data curation

Affiliation Key Laboratory for Prevention and Remediation of Plateau Environmental Damage, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Lanzhou, China
⨯
Anpeng Zhao,

Roles Methodology

Affiliation Key Laboratory for Prevention and Remediation of Plateau Environmental Damage, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Lanzhou, China
⨯
Wenbin Li,

Roles Investigation

Affiliation Key Laboratory for Prevention and Remediation of Plateau Environmental Damage, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Lanzhou, China
⨯
Qiangsheng Feng,

Roles Methodology

Affiliation Key Laboratory for Prevention and Remediation of Plateau Environmental Damage, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Lanzhou, China
⨯
Rong Wang

Roles Funding acquisition, Supervision

* E-mail: wangrong-69@163.com

Affiliations Key Laboratory for Prevention and Remediation of Plateau Environmental Damage, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Lanzhou, China, School of Pharmacy, Lanzhou University, Lanzhou, China
⨯

Effects of intestinal flora on the pharmacokinetics and pharmacodynamics of aspirin in high-altitude hypoxia

Yuemei Sun,
Juanhong Zhang,
Anpeng Zhao,
Wenbin Li,
Qiangsheng Feng,
Rong Wang

Published: March 12, 2020
https://doi.org/10.1371/journal.pone.0230197

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