Pharmacogenetic—Whole blood and intracellular pharmacokinetic—Pharmacodynamic (PG-PK²-PD) relationship of tacrolimus in liver transplant recipients

• Camille Tron ,

  Roles Conceptualization, Formal analysis, Investigation, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: camille.tron@chu-rennes.fr

  Affiliations Rennes 1 University, Rennes University Hospital, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)—UMR_S 1085, Rennes, France, INSERM, CIC 1414 Clinical Investigation Center, Rennes, France

  http://orcid.org/0000-0002-1030-1750

  ⨯
• Jean-Baptiste Woillard,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliations Department of Pharmacology and Toxicology, Limoges University Hospital, Limoges, France, INSERM, UMR 1248, Limoges, France, Limoges University, Limoges, France

  ⨯
• Pauline Houssel-Debry,

  Roles Conceptualization, Resources

  Affiliations INSERM, CIC 1414 Clinical Investigation Center, Rennes, France, Hepato-Biliary and Digestive Surgery Unit, Rennes University Hospital, Rennes, France

  ⨯
• Véronique David,

  Roles Resources

  Affiliations Department of Molecular Genetics and Genomics, Rennes University Hospital, Rennes, France, CNRS, UMR6290, IGDR, Rennes, France

  ⨯
• Caroline Jezequel,

  Roles Conceptualization, Resources

  Affiliation Hepato-Biliary and Digestive Surgery Unit, Rennes University Hospital, Rennes, France

  ⨯
• Michel Rayar,

  Roles Resources

  Affiliations INSERM, CIC 1414 Clinical Investigation Center, Rennes, France, Hepato-Biliary and Digestive Surgery Unit, Rennes University Hospital, Rennes, France

  ⨯
• David Balakirouchenane,

  Roles Investigation, Resources

  Affiliation Assistance Publique-Hôpitaux de Paris (AP-HP), Pharmacokinetics and Pharmacochemistry Department, Cochin Hospital, Paris, France

  ⨯
• Benoit Blanchet,

  Roles Investigation, Resources

  Affiliations Assistance Publique-Hôpitaux de Paris (AP-HP), Pharmacokinetics and Pharmacochemistry Department, Cochin Hospital, Paris, France, CNRS, UMR8638, Faculty of Pharmacy, Paris Descartes University, PRES Sorbonne Paris Cité, Paris, France

  ⨯
• Jean Debord,

  Roles Formal analysis, Methodology

  Affiliations Department of Pharmacology and Toxicology, Limoges University Hospital, Limoges, France, INSERM, UMR 1248, Limoges, France

  ⨯
• Antoine Petitcollin,

  Roles Writing – review & editing

  Affiliation INSERM, CIC 1414 Clinical Investigation Center, Rennes, France

  ⨯
• Mickaël Roussel,

  Roles Investigation, Resources

  Affiliation Haematology Laboratory, Rennes University Hospital, Rennes, France

  ⨯
• Marie-Clémence Verdier,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliations Rennes 1 University, Rennes University Hospital, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)—UMR_S 1085, Rennes, France, INSERM, CIC 1414 Clinical Investigation Center, Rennes, France

  ⨯
• Eric Bellissant,

  Roles Methodology, Writing – review & editing

  Affiliations Rennes 1 University, Rennes University Hospital, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)—UMR_S 1085, Rennes, France, INSERM, CIC 1414 Clinical Investigation Center, Rennes, France

  ⨯
• Florian Lemaitre

  Roles Conceptualization, Methodology, Project administration, Supervision, Writing – original draft

  Affiliations Rennes 1 University, Rennes University Hospital, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)—UMR_S 1085, Rennes, France, INSERM, CIC 1414 Clinical Investigation Center, Rennes, France

  ⨯