Design of composite measure schemes for comparative severity assessment in animal-based neuroscience research: A case study focussed on rat epilepsy models

• Roelof Maarten van Dijk ,

  Roles Conceptualization, Methodology, Supervision, Visualization, Writing – original draft

  ¶‡ These authors share first authorship on this work.

  Affiliation Institute of Pharmacology, Toxicology and Pharmacy, Ludwig-Maximilians-University, Munich, Germany

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• Ines Koska ,

  Roles Data curation, Investigation, Writing – review & editing

  ¶‡ These authors share first authorship on this work.

  Affiliation Institute of Pharmacology, Toxicology and Pharmacy, Ludwig-Maximilians-University, Munich, Germany

  ⨯
• Andre Bleich,

  Roles Funding acquisition, Supervision

  Affiliation Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hannover, Germany

  ⨯
• Rene Tolba,

  Roles Funding acquisition, Supervision

  Affiliation Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hannover, Germany

  ⨯
• Isabel Seiffert,

  Roles Data curation, Investigation

  Affiliation Institute of Pharmacology, Toxicology and Pharmacy, Ludwig-Maximilians-University, Munich, Germany

  ⨯
• Christina Möller,

  Roles Data curation, Investigation

  Affiliation Institute of Pharmacology, Toxicology and Pharmacy, Ludwig-Maximilians-University, Munich, Germany

  ⨯
• Valentina Di Liberto,

  Roles Data curation, Investigation, Supervision

  Affiliation Department of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, Palermo, Italy

  ⨯
• Steven Roger Talbot ,

  Roles Conceptualization, Investigation, Methodology, Software, Writing – original draft, Writing – review & editing

  ¶☯ These authors share last authorship on this work.

  Affiliation Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hannover, Germany

  ⨯
• Heidrun Potschka

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – original draft

  * E-mail: potschka@pharmtox.vetmed.uni-muenchen.de

  ¶☯ These authors share last authorship on this work.

  Affiliation Institute of Pharmacology, Toxicology and Pharmacy, Ludwig-Maximilians-University, Munich, Germany

  http://orcid.org/0000-0003-1506-0252

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