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Open Access
Peer-reviewed
Research Article
IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models
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Anjelika Gasilina ,
Contributed equally to this work with: Anjelika Gasilina, Gurdat Premnauth
Roles Data curation, Formal analysis, Visualization, Writing – original draft, Writing – review & editing
Affiliations Division of Experimental Hematology and Cancer Biology, Children’s Hospital Research Foundation, Cincinnati, Ohio, Unites States of America, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, Unites States of America
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Gurdat Premnauth ,
Contributed equally to this work with: Anjelika Gasilina, Gurdat Premnauth
Roles Data curation, Writing – original draft
Affiliation Department of Chemistry, University of Cincinnati, Cincinnati, Ohio, Unites States of America
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Purujit Gurjar,
Roles Data curation
Affiliation Department of Chemistry, University of Cincinnati, Cincinnati, Ohio, Unites States of America
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Jacek Biesiada,
Roles Data curation
Affiliations Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, Unites States of America, Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, Unites States of America
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Shailaja Hegde,
Roles Data curation
Affiliations Division of Experimental Hematology and Cancer Biology, Children’s Hospital Research Foundation, Cincinnati, Ohio, Unites States of America, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, Unites States of America
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David Milewski,
Roles Data curation, Writing – original draft
Affiliations Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, Unites States of America, Division of Pulmonary Biology, Perinatal Institute, Cincinnati Children’s Hospital Research Foundation, Cincinnati, Ohio, Unites States of America
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Gang Ma,
Roles Data curation
Affiliations Division of Experimental Hematology and Cancer Biology, Children’s Hospital Research Foundation, Cincinnati, Ohio, Unites States of America, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, Unites States of America
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Tanya V. Kalin,
Roles Investigation
Affiliations Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, Unites States of America, Division of Pulmonary Biology, Perinatal Institute, Cincinnati Children’s Hospital Research Foundation, Cincinnati, Ohio, Unites States of America
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Edward Merino,
Roles Data curation, Formal analysis
Affiliation Department of Chemistry, University of Cincinnati, Cincinnati, Ohio, Unites States of America
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Jarek Meller,
Roles Data curation, Formal analysis
Affiliations Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, Unites States of America, Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, Unites States of America
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William Seibel,
Roles Data curation, Formal analysis
Affiliations Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, Unites States of America, Division of Oncology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, Unites States of America
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José A. Cancelas,
Roles Supervision
Affiliations Division of Experimental Hematology and Cancer Biology, Children’s Hospital Research Foundation, Cincinnati, Ohio, Unites States of America, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, Unites States of America, Hoxworth Blood Center, University of Cincinnati Academic Health Center, Cincinnati, Ohio, Unites States of America
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Lisa Privette Vinnedge,
Roles Data curation, Formal analysis, Writing – original draft
Affiliations Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, Unites States of America, Division of Oncology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, Unites States of America
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Nicolas N. Nassar
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: nicolas.nassar@cchmc.org
Affiliations Division of Experimental Hematology and Cancer Biology, Children’s Hospital Research Foundation, Cincinnati, Ohio, Unites States of America, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, Unites States of America
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IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models
- Anjelika Gasilina,
- Gurdat Premnauth,
- Purujit Gurjar,
- Jacek Biesiada,
- Shailaja Hegde,
- David Milewski,
- Gang Ma,
- Tanya V. Kalin,
- Edward Merino,
- Jarek Meller
![PLOS](/resource/img/logo-plos.png)
- Published: March 12, 2020
- https://doi.org/10.1371/journal.pone.0229801