IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models

• Anjelika Gasilina ,

  Contributed equally to this work with: Anjelika Gasilina, Gurdat Premnauth

  Roles Data curation, Formal analysis, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Division of Experimental Hematology and Cancer Biology, Children’s Hospital Research Foundation, Cincinnati, Ohio, Unites States of America, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, Unites States of America

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• Gurdat Premnauth ,

  Contributed equally to this work with: Anjelika Gasilina, Gurdat Premnauth

  Roles Data curation, Writing – original draft

  Affiliation Department of Chemistry, University of Cincinnati, Cincinnati, Ohio, Unites States of America

  http://orcid.org/0000-0002-9707-5708

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• Purujit Gurjar,

  Roles Data curation

  Affiliation Department of Chemistry, University of Cincinnati, Cincinnati, Ohio, Unites States of America

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• Jacek Biesiada,

  Roles Data curation

  Affiliations Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, Unites States of America, Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, Unites States of America

  ⨯
• Shailaja Hegde,

  Roles Data curation

  Affiliations Division of Experimental Hematology and Cancer Biology, Children’s Hospital Research Foundation, Cincinnati, Ohio, Unites States of America, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, Unites States of America

  ⨯
• David Milewski,

  Roles Data curation, Writing – original draft

  Affiliations Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, Unites States of America, Division of Pulmonary Biology, Perinatal Institute, Cincinnati Children’s Hospital Research Foundation, Cincinnati, Ohio, Unites States of America

  ⨯
• Gang Ma,

  Roles Data curation

  Affiliations Division of Experimental Hematology and Cancer Biology, Children’s Hospital Research Foundation, Cincinnati, Ohio, Unites States of America, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, Unites States of America

  ⨯
• Tanya V. Kalin,

  Roles Investigation

  Affiliations Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, Unites States of America, Division of Pulmonary Biology, Perinatal Institute, Cincinnati Children’s Hospital Research Foundation, Cincinnati, Ohio, Unites States of America

  ⨯
• Edward Merino,

  Roles Data curation, Formal analysis

  Affiliation Department of Chemistry, University of Cincinnati, Cincinnati, Ohio, Unites States of America

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• Jarek Meller,

  Roles Data curation, Formal analysis

  Affiliations Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, Unites States of America, Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, Unites States of America

  ⨯
• William Seibel,

  Roles Data curation, Formal analysis

  Affiliations Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, Unites States of America, Division of Oncology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, Unites States of America

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• José A. Cancelas,

  Roles Supervision

  Affiliations Division of Experimental Hematology and Cancer Biology, Children’s Hospital Research Foundation, Cincinnati, Ohio, Unites States of America, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, Unites States of America, Hoxworth Blood Center, University of Cincinnati Academic Health Center, Cincinnati, Ohio, Unites States of America

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• Lisa Privette Vinnedge,

  Roles Data curation, Formal analysis, Writing – original draft

  Affiliations Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, Unites States of America, Division of Oncology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, Unites States of America

  http://orcid.org/0000-0003-2087-4920

  ⨯
• Nicolas N. Nassar

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: nicolas.nassar@cchmc.org

  Affiliations Division of Experimental Hematology and Cancer Biology, Children’s Hospital Research Foundation, Cincinnati, Ohio, Unites States of America, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, Unites States of America

  http://orcid.org/0000-0003-0481-4784

  ⨯