DMSO-mediated curing of several yeast prion variants involves Hsp104 expression and protein solubilization, and is decreased in several autophagy related gene (atg) mutants

Jane E. Dorweiler; Joanna O. Obaoye; Mitch J. Oddo; Francesca M. Shilati; Grace M. Scheidemantle; Thomas J. Coleman; Jacob A. Reilly; Gregory R. Smith; Anita L. Manogaran

doi:10.1371/journal.pone.0229796

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Open Access

Peer-reviewed

Research Article

DMSO-mediated curing of several yeast prion variants involves Hsp104 expression and protein solubilization, and is decreased in several autophagy related gene (atg) mutants

Jane E. Dorweiler,

Roles Investigation, Methodology, Supervision, Validation, Writing – review & editing

Affiliation Department of Biological Sciences, Marquette University, Milwaukee, WI, United States of America
⨯
Joanna O. Obaoye,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Department of Biological Sciences, Marquette University, Milwaukee, WI, United States of America
⨯
Mitch J. Oddo,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Biological Sciences, Marquette University, Milwaukee, WI, United States of America
⨯
Francesca M. Shilati,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Biological Sciences, Marquette University, Milwaukee, WI, United States of America
⨯
Grace M. Scheidemantle,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Biological Sciences, Marquette University, Milwaukee, WI, United States of America
⨯
Thomas J. Coleman,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Biology, Lakeland University, Plymouth, WI, United States of America
⨯
Jacob A. Reilly,

Roles Investigation

Affiliation Department of Biological Sciences, Marquette University, Milwaukee, WI, United States of America
⨯
Gregory R. Smith,

Roles Formal analysis, Investigation, Supervision, Writing – review & editing

Affiliation Department of Biology, Lakeland University, Plymouth, WI, United States of America
⨯
Anita L. Manogaran

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: anita.manogaran@marquette.edu

Affiliation Department of Biological Sciences, Marquette University, Milwaukee, WI, United States of America

http://orcid.org/0000-0003-0844-1479

⨯

DMSO-mediated curing of several yeast prion variants involves Hsp104 expression and protein solubilization, and is decreased in several autophagy related gene (atg) mutants

Jane E. Dorweiler,
Joanna O. Obaoye,
Mitch J. Oddo,
Francesca M. Shilati,
Grace M. Scheidemantle,
Thomas J. Coleman,
Jacob A. Reilly,
Gregory R. Smith,
Anita L. Manogaran

Published: March 5, 2020
https://doi.org/10.1371/journal.pone.0229796

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Autophagic cell death
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Cell cycle and cell division
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Quality control
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Flow cytometry
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Heat treatment
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Monomers
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Yeast
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Amyotrophic lateral sclerosis
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