Pharmacokinetics and safety after once and twice a day doses of meclizine hydrochloride administered to children with achondroplasia

Hiroshi Kitoh; Masaki Matsushita; Kenichi Mishima; Tadashi Nagata; Yasunari Kamiya; Kohei Ueda; Yachiyo Kuwatsuka; Hiroshi Morikawa; Yasuhiro Nakai; Naoki Ishiguro

doi:10.1371/journal.pone.0229639

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Open Access

Peer-reviewed

Research Article

Pharmacokinetics and safety after once and twice a day doses of meclizine hydrochloride administered to children with achondroplasia

Hiroshi Kitoh ,

Roles Data curation, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

* E-mail: hkitoh420@gmail.com

Affiliations Department of Orthopaedic Surgery, Aichi Children’s Health and Medical Center, Obu, Aichi, Japan, Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan

http://orcid.org/0000-0001-6271-1586

⨯
Masaki Matsushita,

Roles Data curation, Investigation

Affiliation Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan
⨯
Kenichi Mishima,

Roles Data curation, Investigation

Affiliation Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan
⨯
Tadashi Nagata,

Roles Investigation

Affiliation Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan
⨯
Yasunari Kamiya,

Roles Investigation

Affiliation Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan
⨯
Kohei Ueda,

Roles Conceptualization, Project administration, Writing – review & editing

Affiliation Department of Advanced Medicine, Nagoya University Hospital, Showa-ku, Nagoya, Aichi, Japan
⨯
Yachiyo Kuwatsuka,

Roles Formal analysis, Methodology

Affiliation Department of Advanced Medicine, Nagoya University Hospital, Showa-ku, Nagoya, Aichi, Japan
⨯
Hiroshi Morikawa,

Roles Formal analysis, Validation

Affiliation Ina Research Inc, Ina, Nagano, Japan
⨯
Yasuhiro Nakai,

Roles Formal analysis, Writing – review & editing

Affiliation Department of Advanced Medicine, Nagoya University Hospital, Showa-ku, Nagoya, Aichi, Japan
⨯
Naoki Ishiguro

Roles Supervision

Affiliation Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan
⨯

Pharmacokinetics and safety after once and twice a day doses of meclizine hydrochloride administered to children with achondroplasia

Hiroshi Kitoh,
Masaki Matsushita,
Kenichi Mishima,
Tadashi Nagata,
Yasunari Kamiya,
Kohei Ueda,
Yachiyo Kuwatsuka,
Hiroshi Morikawa,
Yasuhiro Nakai,
Naoki Ishiguro

Published: April 13, 2020
https://doi.org/10.1371/journal.pone.0229639

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