A microbiome and metabolomic signature of phases of cutaneous healing identified by profiling sequential acute wounds of human skin: An exploratory study

Mohammed Ashrafi; Yun Xu; Howbeer Muhamadali; Iain White; Maxim Wilkinson; Katherine Hollywood; Mohamed Baguneid; Royston Goodacre; Ardeshir Bayat

doi:10.1371/journal.pone.0229545

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Open Access

Peer-reviewed

Research Article

A microbiome and metabolomic signature of phases of cutaneous healing identified by profiling sequential acute wounds of human skin: An exploratory study

Mohammed Ashrafi,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations Plastic & Reconstructive Surgery Research, Division of Musculoskeletal & Dermatological Sciences, NIHR Manchester Biomedical Research Centre (BRC), University of Manchester, Manchester, United Kingdom, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, United Kingdom, Bioengineering Group, School of Materials, University of Manchester, Manchester, United Kingdom

http://orcid.org/0000-0003-3704-9134

⨯
Yun Xu,

Roles Formal analysis, Writing – review & editing

Affiliations School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom, Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom
⨯
Howbeer Muhamadali,

Roles Data curation, Writing – review & editing

Affiliations School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom, Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom
⨯
Iain White,

Roles Investigation, Methodology, Writing – review & editing

Affiliations School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom, Laboratory for Environmental and Life Sciences, University of Nova Gorica, Nova Gorica, Slovenia
⨯
Maxim Wilkinson,

Roles Investigation

Affiliation School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom
⨯
Katherine Hollywood,

Roles Investigation

Affiliation Manchester Centre for Synthetic Biology of Fine and Speciality Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom
⨯
Mohamed Baguneid,

Roles Supervision, Writing – review & editing

Affiliation Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, United Kingdom
⨯
Royston Goodacre,

Roles Methodology, Supervision, Writing – review & editing

Affiliations School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom, Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom
⨯
Ardeshir Bayat

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

* E-mail: ardeshir.bayat@manchester.ac.uk

Affiliations Plastic & Reconstructive Surgery Research, Division of Musculoskeletal & Dermatological Sciences, NIHR Manchester Biomedical Research Centre (BRC), University of Manchester, Manchester, United Kingdom, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, United Kingdom, Bioengineering Group, School of Materials, University of Manchester, Manchester, United Kingdom
⨯

A microbiome and metabolomic signature of phases of cutaneous healing identified by profiling sequential acute wounds of human skin: An exploratory study

Mohammed Ashrafi,
Yun Xu,
Howbeer Muhamadali,
Iain White,
Maxim Wilkinson,
Katherine Hollywood,
Mohamed Baguneid,
Royston Goodacre,
Ardeshir Bayat

Published: February 27, 2020
https://doi.org/10.1371/journal.pone.0229545

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