Equiprobable discrete models of site-specific substitution rates underestimate the extent of rate variability

• Frank Mannino,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Bioinformatics Research Center, North Carolina State University, Raleigh, NC, United States of America

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• Sadie Wisotsky,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Bioinformatics Research Center, North Carolina State University, Raleigh, NC, United States of America, Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA, United States of America

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• Sergei L. Kosakovsky Pond,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA, United States of America

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• Spencer V. Muse

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: muse@ncsu.edu

  Affiliations Bioinformatics Research Center, North Carolina State University, Raleigh, NC, United States of America, Department of Statistics, North Carolina State University, Raleigh, NC, United States of America

  http://orcid.org/0000-0003-0104-0728

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