Cigarette smoke downregulates Nur77 to exacerbate inflammation in chronic obstructive pulmonary disease (COPD)

Aravind T. Reddy; Sowmya P. Lakshmi; Asoka Banno; Shantanu Krishna Jadhav; Ishaque Pulikkal Kadamberi; Seong C. Kim; Raju C. Reddy

doi:10.1371/journal.pone.0229256

Loading metrics

Open Access

Peer-reviewed

Research Article

Cigarette smoke downregulates Nur77 to exacerbate inflammation in chronic obstructive pulmonary disease (COPD)

Aravind T. Reddy,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, United States of America

http://orcid.org/0000-0001-8628-3467

⨯
Sowmya P. Lakshmi,

Roles Data curation, Formal analysis, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, United States of America
⨯
Asoka Banno,

Roles Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Shantanu Krishna Jadhav,

Roles Data curation, Investigation

Affiliations Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, United States of America
⨯
Ishaque Pulikkal Kadamberi,

Roles Data curation, Investigation

Affiliations Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, United States of America
⨯
Seong C. Kim,

Roles Data curation, Investigation

Affiliations Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, United States of America
⨯
Raju C. Reddy

Roles Conceptualization, Funding acquisition, Investigation, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: reddyrc@upmc.edu

Affiliations Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, United States of America

http://orcid.org/0000-0001-5136-817X

⨯

Cigarette smoke downregulates Nur77 to exacerbate inflammation in chronic obstructive pulmonary disease (COPD)

Aravind T. Reddy,
Sowmya P. Lakshmi,
Asoka Banno,
Shantanu Krishna Jadhav,
Ishaque Pulikkal Kadamberi,
Seong C. Kim,
Raju C. Reddy

Published: February 21, 2020
https://doi.org/10.1371/journal.pone.0229256

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Chronic obstructive pulmonary disease
Is the Subject Area "Chronic obstructive pulmonary disease" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Inflammatory diseases
Is the Subject Area "Inflammatory diseases" applicable to this article?

Thanks for your feedback.
Transcription factors
Is the Subject Area "Transcription factors" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Smoking habits
Is the Subject Area "Smoking habits" applicable to this article?

Thanks for your feedback.
Epithelial cells
Is the Subject Area "Epithelial cells" applicable to this article?

Thanks for your feedback.
Transcriptional control
Is the Subject Area "Transcriptional control" applicable to this article?

Thanks for your feedback.