CD20 is dispensable for B-cell receptor signaling but is required for proper actin polymerization, adhesion and migration of malignant B cells

Veronika Kozlova; Aneta Ledererova; Adriana Ladungova; Helena Peschelova; Pavlina Janovska; Aleksander Slusarczyk; Joanna Domagala; Pavel Kopcil; Viera Vakulova; Jan Oppelt; Vitezslav Bryja; Michael Doubek; Jiri Mayer; Sarka Pospisilova; Michal Smida

doi:10.1371/journal.pone.0229170

Loading metrics

Open Access

Peer-reviewed

Research Article

CD20 is dispensable for B-cell receptor signaling but is required for proper actin polymerization, adhesion and migration of malignant B cells

Veronika Kozlova,

Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

Affiliations Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic, Department of Internal Medicine - Hematology and Oncology, Medical Faculty of Masaryk University and University Hospital Brno, Brno, Czech Republic
⨯
Aneta Ledererova,

Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

Affiliations Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic, Department of Internal Medicine - Hematology and Oncology, Medical Faculty of Masaryk University and University Hospital Brno, Brno, Czech Republic
⨯
Adriana Ladungova,

Roles Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliation Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic
⨯
Helena Peschelova,

Roles Investigation, Methodology

Affiliation Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic
⨯
Pavlina Janovska,

Roles Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliation Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic
⨯
Aleksander Slusarczyk,

Roles Investigation, Methodology

Affiliation Department of Immunology, Medical University of Warsaw, Warsaw, Poland
⨯
Joanna Domagala,

Roles Investigation, Methodology

Affiliation Department of Immunology, Medical University of Warsaw, Warsaw, Poland
⨯
Pavel Kopcil,

Roles Formal analysis, Investigation, Validation

Affiliation Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic
⨯
Viera Vakulova,

Roles Investigation, Visualization

Affiliation Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic
⨯
Jan Oppelt,

Roles Data curation, Software, Visualization

Affiliation Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic

http://orcid.org/0000-0002-3076-4840

⨯
Vitezslav Bryja,

Roles Formal analysis, Supervision, Writing – review & editing

Affiliation Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic
⨯
Michael Doubek,

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

Affiliations Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic, Department of Internal Medicine - Hematology and Oncology, Medical Faculty of Masaryk University and University Hospital Brno, Brno, Czech Republic
⨯
Jiri Mayer,

Roles Conceptualization, Project administration, Resources, Supervision

Affiliations Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic, Department of Internal Medicine - Hematology and Oncology, Medical Faculty of Masaryk University and University Hospital Brno, Brno, Czech Republic
⨯
Sarka Pospisilova,

Roles Conceptualization, Resources, Supervision

Affiliations Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic, Department of Internal Medicine - Hematology and Oncology, Medical Faculty of Masaryk University and University Hospital Brno, Brno, Czech Republic
⨯
Michal Smida

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Visualization, Writing – original draft

* E-mail: michal.smida@ceitec.muni.cz

Affiliations Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic, Department of Internal Medicine - Hematology and Oncology, Medical Faculty of Masaryk University and University Hospital Brno, Brno, Czech Republic

http://orcid.org/0000-0002-7335-3435

⨯

CD20 is dispensable for B-cell receptor signaling but is required for proper actin polymerization, adhesion and migration of malignant B cells

Veronika Kozlova,
Aneta Ledererova,
Adriana Ladungova,
Helena Peschelova,
Pavlina Janovska,
Aleksander Slusarczyk,
Joanna Domagala,
Pavel Kopcil,
Viera Vakulova,
Jan Oppelt

Published: March 25, 2020
https://doi.org/10.1371/journal.pone.0229170

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

B cells
Is the Subject Area "B cells" applicable to this article?

Thanks for your feedback.
Flow cytometry
Is the Subject Area "Flow cytometry" applicable to this article?

Thanks for your feedback.
Chemokines
Is the Subject Area "Chemokines" applicable to this article?

Thanks for your feedback.
Raji cells
Is the Subject Area "Raji cells" applicable to this article?

Thanks for your feedback.
Cell staining
Is the Subject Area "Cell staining" applicable to this article?

Thanks for your feedback.
Calcium signaling
Is the Subject Area "Calcium signaling" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Actin polymerization
Is the Subject Area "Actin polymerization" applicable to this article?

Thanks for your feedback.