Genetic heterogeneity of the Spy1336/R28—Spy1337 virulence axis in Streptococcus pyogenes and effect on gene transcript levels and pathogenesis

• Jesus M. Eraso ,

  Contributed equally to this work with: Jesus M. Eraso, Priyanka Kachroo

  Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Center for Molecular and Translational Human Infectious Diseases Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, United States of America

  http://orcid.org/0000-0003-1383-8702

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• Priyanka Kachroo ,

  Contributed equally to this work with: Jesus M. Eraso, Priyanka Kachroo

  Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Center for Molecular and Translational Human Infectious Diseases Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, United States of America

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• Randall J. Olsen,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Center for Molecular and Translational Human Infectious Diseases Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, United States of America, Departments of Pathology and Laboratory Medicine and Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America

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• Stephen B. Beres,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation Center for Molecular and Translational Human Infectious Diseases Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, United States of America

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• Luchang Zhu,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Center for Molecular and Translational Human Infectious Diseases Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, United States of America

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• Traci Badu,

  Roles Data curation, Investigation

  Current address: Neuroscience Department, Macalester College, St. Paul, Minnesota, United States of America

  Affiliation Center for Molecular and Translational Human Infectious Diseases Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, United States of America

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• Sydney Shannon,

  Roles Data curation, Investigation

  Current address: Biomedical Engineering Department, University of Rochester, Rochester, New York, United States of America

  Affiliation Center for Molecular and Translational Human Infectious Diseases Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, United States of America

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• Concepcion C. Cantu,

  Roles Investigation

  Affiliation Center for Molecular and Translational Human Infectious Diseases Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, United States of America

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• Matthew Ojeda Saavedra,

  Roles Investigation

  Affiliation Center for Molecular and Translational Human Infectious Diseases Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, United States of America

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• Samantha L. Kubiak,

  Roles Investigation

  Current address: University of North Texas Health Science Center, School of Health Professions, Fort Worth, Texas, United States of America

  Affiliation Center for Molecular and Translational Human Infectious Diseases Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, United States of America

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• Adeline R. Porter,

  Roles Investigation

  Affiliation Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

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• Frank R. DeLeo,

  Roles Formal analysis, Funding acquisition, Supervision, Writing – review & editing

  Affiliation Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

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• James M. Musser

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jmmusser@houstonmethodist.org

  Affiliations Center for Molecular and Translational Human Infectious Diseases Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, United States of America, Departments of Pathology and Laboratory Medicine and Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America

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