The stochastic nature of errors in next-generation sequencing of circulating cell-free DNA

• David A. Nix ,

  Contributed equally to this work with: David A. Nix, Sabine Hellwig

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Writing – original draft, Writing – review & editing

  Affiliation Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

  ⨯
• Sabine Hellwig ,

  Contributed equally to this work with: David A. Nix, Sabine Hellwig

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation ARUP Laboratories, Salt Lake City, Utah, United States of America

  ⨯
• Christopher Conley,

  Roles Formal analysis, Methodology, Software, Writing – review & editing

  Affiliation Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

  ⨯
• Alun Thomas,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliation Divisions of Genetic Epidemiology and Public Health, Department of Family and Preventative Medicine, University of Utah, Salt Lake City, Utah, United States of America

  ⨯
• Carrie L. Fuertes,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pathology, University of Utah, Salt Lake City, Utah, United States of America

  ⨯
• Cindy L. Hamil,

  Roles Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pathology, University of Utah, Salt Lake City, Utah, United States of America

  ⨯
• Preetida J. Bhetariya,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Department of Human Genetics, University of Utah, Salt Lake City, Utah, United States of America

  ⨯
• Ignacio Garrido-Laguna,

  Roles Resources, Writing – review & editing

  Affiliation Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

  ⨯
• Gabor T. Marth,

  Roles Resources, Writing – review & editing

  Affiliation Department of Human Genetics, University of Utah, Salt Lake City, Utah, United States of America

  ⨯
• Mary P. Bronner,

  Roles Conceptualization, Resources, Supervision, Writing – review & editing

  Affiliation Department of Pathology, University of Utah, Salt Lake City, Utah, United States of America

  ⨯
• Hunter R. Underhill

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: Hunter.Underhill@hsc.utah.edu

  Affiliations Division of Medical Genetics, Department of Pediatrics, University of Utah, Salt Lake City, Utah, United States of America, Department of Radiology, University of Utah, Salt Lake City, Utah, United States of America

  http://orcid.org/0000-0002-7389-1487

  ⨯