Bypassing ubiquitination enables LAT recycling to the cell surface and enhanced signaling in T cells

Lakshmi Balagopalan; Hiba Malik; Katherine M. McIntire; Joseph A. Garvey; Tiffany Nguyen; Ana B. Rodriguez-Peña; Lawrence E. Samelson

doi:10.1371/journal.pone.0229036

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Open Access

Peer-reviewed

Research Article

Bypassing ubiquitination enables LAT recycling to the cell surface and enhanced signaling in T cells

Lakshmi Balagopalan ,

Roles Conceptualization, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

* E-mail: balagopl@mail.nih.gov (LB); samelsonl@helix.nih.gov (LES)

Affiliation Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

http://orcid.org/0000-0002-6371-0101

⨯
Hiba Malik,

Roles Investigation, Methodology, Project administration

Affiliation Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Katherine M. McIntire,

Roles Investigation, Methodology

Affiliation Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Joseph A. Garvey,

Roles Investigation, Methodology

Affiliation Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Tiffany Nguyen,

Roles Investigation, Methodology

Affiliation Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Ana B. Rodriguez-Peña,

Roles Methodology

Affiliation Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Lawrence E. Samelson

Roles Supervision, Writing – review & editing

* E-mail: balagopl@mail.nih.gov (LB); samelsonl@helix.nih.gov (LES)

Affiliation Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Bypassing ubiquitination enables LAT recycling to the cell surface and enhanced signaling in T cells

Lakshmi Balagopalan,
Hiba Malik,
Katherine M. McIntire,
Joseph A. Garvey,
Tiffany Nguyen,
Ana B. Rodriguez-Peña,
Lawrence E. Samelson

Published: February 21, 2020
https://doi.org/10.1371/journal.pone.0229036

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T cells
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Ubiquitination
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Lysosomes
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Cell membranes
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Flow cytometry
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Endocytosis
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Cloning
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Phosphorylation
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