Estrogen activates pyruvate kinase M2 and increases the growth of TSC2-deficient cells

• Yiyang Lu ,

  Contributed equally to this work with: Yiyang Lu, Xiaolei Liu

  Roles Data curation, Investigation, Methodology, Software, Writing – review & editing

  Affiliation University of Cincinnati College of Medicine, Department of Internal Medicine, Cincinnati, OH, United States of America

  ⨯
• Xiaolei Liu ,

  Contributed equally to this work with: Yiyang Lu, Xiaolei Liu

  Roles Data curation, Funding acquisition, Investigation, Methodology, Project administration, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation University of Cincinnati College of Medicine, Department of Internal Medicine, Cincinnati, OH, United States of America

  ⨯
• Erik Zhang,

  Roles Investigation

  Affiliation University of Cincinnati College of Medicine, Department of Internal Medicine, Cincinnati, OH, United States of America

  ⨯
• Elizabeth J. Kopras,

  Roles Writing – review & editing

  Affiliation University of Cincinnati College of Medicine, Department of Internal Medicine, Cincinnati, OH, United States of America

  http://orcid.org/0000-0001-5429-2609

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• Eric P. Smith,

  Roles Writing – review & editing

  Affiliation University of Cincinnati College of Medicine, Department of Internal Medicine, Cincinnati, OH, United States of America

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• Aristotelis Astreinidis,

  Roles Writing – review & editing

  Affiliation Division of Pediatric Nephrology, Department of Pediatrics, College of Medicine, University of Tennessee Health Sciences Center and Tuberous Sclerosis Complex Center of Excellence, Le Bonheur Children’s Hospital, Memphis, TN, United States of America

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• Chenggang Li,

  Roles Investigation

  Affiliations University of Cincinnati College of Medicine, Department of Internal Medicine, Cincinnati, OH, United States of America, State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China

  ⨯
• Yuet-Kin Leung,

  Roles Writing – review & editing

  Affiliation College of Medicine Department of Pharmacology and Toxicology, the University of Arkansas for Medical Science (UAMS), Little Rock, AR, United States of America

  http://orcid.org/0000-0003-2063-277X

  ⨯
• Shuk-Mei Ho,

  Roles Writing – review & editing

  Affiliation College of Medicine Department of Pharmacology and Toxicology, the University of Arkansas for Medical Science (UAMS), Little Rock, AR, United States of America

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• Jane J. Yu

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: yuj9@ucmail.uc.edu

  Affiliation University of Cincinnati College of Medicine, Department of Internal Medicine, Cincinnati, OH, United States of America

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