Simultaneous quantification of palbociclib, ribociclib and letrozole in human plasma by a new LC-MS/MS method for clinical application

Bianca Posocco; Mauro Buzzo; Ariana Soledad Poetto; Marco Orleni; Sara Gagno; Martina Zanchetta; Valentina Iacuzzi; Michela Guardascione; Fabio Puglisi; Debora Basile; Giacomo Pelizzari; Elena Marangon; Giuseppe Toffoli

doi:10.1371/journal.pone.0228822

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Open Access

Peer-reviewed

Research Article

Simultaneous quantification of palbociclib, ribociclib and letrozole in human plasma by a new LC-MS/MS method for clinical application

Bianca Posocco ,

Roles Investigation, Methodology, Writing – original draft

* E-mail: bposocco@cro.it

Affiliation Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy

http://orcid.org/0000-0002-3424-8827

⨯
Mauro Buzzo,

Roles Investigation, Methodology

Affiliation Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
⨯
Ariana Soledad Poetto,

Roles Investigation, Methodology

Affiliations Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy, Doctoral School in Pharmacological Sciences, University of Padova, Padova, Italy
⨯
Marco Orleni,

Roles Investigation

Affiliation Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
⨯
Sara Gagno,

Roles Investigation

Affiliation Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
⨯
Martina Zanchetta,

Roles Investigation

Affiliations Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy, Department of Chemical and Pharmaceutical Sciences, University of Trieste, Trieste, Italy
⨯
Valentina Iacuzzi,

Roles Investigation

Affiliations Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy, Doctoral School in Nanotechnology, University of Trieste, Trieste, Italy
⨯
Michela Guardascione,

Roles Resources

Affiliation Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
⨯
Fabio Puglisi,

Roles Conceptualization, Resources

Affiliations Department of Medicine (DAME), University of Udine, Udine, Italy, Department of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
⨯
Debora Basile,

Roles Resources

Affiliations Department of Medicine (DAME), University of Udine, Udine, Italy, Department of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
⨯
Giacomo Pelizzari,

Roles Resources

Affiliations Department of Medicine (DAME), University of Udine, Udine, Italy, Department of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
⨯
Elena Marangon,

Roles Conceptualization, Methodology

Affiliation Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
⨯
Giuseppe Toffoli

Roles Conceptualization, Supervision

Affiliation Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
⨯

Simultaneous quantification of palbociclib, ribociclib and letrozole in human plasma by a new LC-MS/MS method for clinical application

Bianca Posocco,
Mauro Buzzo,
Ariana Soledad Poetto,
Marco Orleni,
Sara Gagno,
Martina Zanchetta,
Valentina Iacuzzi,
Michela Guardascione,
Fabio Puglisi,
Debora Basile

Published: February 7, 2020
https://doi.org/10.1371/journal.pone.0228822

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