Cell-free hemoglobin increases inflammation, lung apoptosis, and microvascular permeability in murine polymicrobial sepsis

• Jamie E. Meegan,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – review & editing

  Affiliation Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, United States of America

  http://orcid.org/0000-0002-2644-676X

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• Ciara M. Shaver,

  Roles Conceptualization, Investigation, Methodology, Supervision, Visualization, Writing – review & editing

  Affiliation Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, United States of America

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• Nathan D. Putz,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliation Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, United States of America

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• Jordan J. Jesse,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliation Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, United States of America

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• Stuart R. Landstreet,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliation Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, United States of America

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• Han Noo Ri Lee,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliation Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, United States of America

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• Tatiana N. Sidorova,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliation Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, United States of America

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• J. Brennan McNeil,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliation Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, United States of America

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• James L. Wynn,

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

  Affiliation Departments of Pediatrics, Pathology, Immunology, and Experimental Medicine, University of Florida Health, Gainesville, FL, United States of America

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• Joyce Cheung-Flynn,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Division of Vascular Surgery, Vanderbilt University Medical Center, Nashville, TN, United States of America

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• Padmini Komalavilas,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Division of Vascular Surgery, Vanderbilt University Medical Center, Nashville, TN, United States of America

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• Colleen M. Brophy,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Division of Vascular Surgery, Vanderbilt University Medical Center, Nashville, TN, United States of America

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• Lorraine B. Ware,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Writing – review & editing

  Affiliations Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, United States of America, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States of America

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• Julie A. Bastarache

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: julie.bastarache@vumc.org

  Affiliations Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, United States of America, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States of America, Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, United States of America

  http://orcid.org/0000-0003-0458-6507

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