GPCR-induced YAP activation sensitizes fibroblasts to profibrotic activity of TGFβ1

Katarina Zmajkovicova; Yasmina Bauer; Katalin Menyhart; Marie Schnoebelen; Diego Freti; Maxime Boucher; Bérengère Renault; Rolf Studer; Magdalena Birker-Robaczewska; Axel Klenk; Oliver Nayler; John Gatfield

doi:10.1371/journal.pone.0228195

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Open Access

Peer-reviewed

Research Article

GPCR-induced YAP activation sensitizes fibroblasts to profibrotic activity of TGFβ1

Katarina Zmajkovicova,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliation Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland
⨯
Yasmina Bauer,

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization

Affiliation Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland
⨯
Katalin Menyhart,

Roles Data curation

Affiliation Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland
⨯
Marie Schnoebelen,

Roles Data curation, Investigation

Affiliation Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland

http://orcid.org/0000-0001-7571-4698

⨯
Diego Freti,

Roles Data curation, Investigation

Affiliation Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland
⨯
Maxime Boucher,

Roles Data curation, Investigation

Affiliation Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland
⨯
Bérengère Renault,

Roles Data curation, Investigation

Affiliation Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland
⨯
Rolf Studer,

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliation Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland
⨯
Magdalena Birker-Robaczewska,

Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing

Affiliation Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland
⨯
Axel Klenk,

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliation Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland
⨯
Oliver Nayler ,

Roles Supervision, Writing – review & editing

¶‡ These authors are joint senior authors on this work.

Affiliation Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland
⨯
John Gatfield

Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – review & editing

* E-mail: john.gatfield@idorsia.com

¶‡ These authors are joint senior authors on this work.

Affiliation Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland

http://orcid.org/0000-0003-1617-8500

⨯

GPCR-induced YAP activation sensitizes fibroblasts to profibrotic activity of TGFβ1

Katarina Zmajkovicova,
Yasmina Bauer,
Katalin Menyhart,
Marie Schnoebelen,
Diego Freti,
Maxime Boucher,
Bérengère Renault,
Rolf Studer,
Magdalena Birker-Robaczewska,
Axel Klenk

Published: February 13, 2020
https://doi.org/10.1371/journal.pone.0228195

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Fibroblasts
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Thrombin
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G protein coupled receptors
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Gene expression
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Fibrosis
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Scanning electron microscopy
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Nuclear staining
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Immunoprecipitation
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